Licensed Genetic Counselor

SenterJamiesonLeigh

Associate Professor Clinical, Human Genetics

Comprehensive Cancer Center
2012 Kenny Road
Columbus, OH 43221

614-293-6694
Leigha.Senter@osumc.edu

Licenses:

  • Licensed genetic counselor: State Medical Board of Ohio, 2013 - present
  • Certified genetic counselor: American Board of Genetic Counseling, 1993 - present
  • Certified genetic counselor: American Board of Medical Genetics, 1987 - present
Specialty interests: 

Cancer genetics

Clinical interests: 

Ms. Senter provides cancer risk assessment and counseling to individuals with a family history of cancer. Cancer genetic consultation requires documentation of cancers in the family, risk assessment, screening recommendations and incorporation of genetic testing as necessary. To schedule an appointment, call 614-293-6694 or toll free at 1-888-329-1654.

Research interests: 

Ms. Senter’s research interests are in cancer genetics. She has a particular interest in PMS2-associated Lynch syndrome, a hereditary colon and endometrial cancer syndrome.

Ms. Senter is a co-investigator and coordinator of multiple cancer genetics studies including one study aimed at determining hereditary components of chronic lymphocytic leukemia (CLL). The researchers involved in this study plan to enroll 500 individuals with CLL and their relatives to learn more about the heritability of CLL. She also is a co-investigator and coordinator for multiple international collaborative studies for individuals with BRCA gene mutations. These include longterm follow-up studies as well as genetic modifier investigations.

Education

MS: Genetic counseling, University of Pittsburgh, 2003
BS: Molecular genetics, The Ohio State University, 2000

Honors:
  • National Society of Genetic Counselors Leadership Award - Outstanding Volunteer, National Society of Genetic Counselors, 2012 - present

Professional activities:

  • Expedited reviewer, Biomedical Institutional Review Board, The Ohio State University, 2007 - present
  • Member, Biomedical Institutional Review Board, The Ohio State University, 2006 - 2011
  • Chair, Audrey Heimler Special Projects Committee, National Society of Genetic Counselors, 2009 - 2010
  • Certification examination item writer, American Board of Genetic Counseling, 2009 - 2010

Chapters in Books

Pilarski R, Hampel H, Eng C. "PTEN Hamartoma Tumor Syndrome." In NORD Guide to Rare Disorders. Edited by National Organization of Rare Disorders. -. Philadelphia, PA, US|USA: Lippincott Williams and Wilkins, January 2002

Pilarski, R, Nagy, R. "Genetic Testing by Cancer Site: Endocrine System." In Cancer: Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics. -. Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins, May 2013

Pilarski, R, Nagy, R. "Genetic Testing by Cancer Site: Endocrine System." In CANCER: Principles and Practice of Oncology. -. Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins, December 2014

Pilarski, R, Nagy R. "Genetic Testing in the Endocrine System." In CANCER: Principles and Practice of Oncology, Primer of the Molecular Biology of Cancer. -. Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins, January 2015

Editorial Activities

Present activities:
  • Community Oncology
2007-2008:
  • Journal of Genetic Counseling
2006-2008:
  • Genetics in Medicine
2004-2008:
  • Journal of Medical Genetics

Journal Articles

Clendenning M; Hampel H; LaJeunesse J; Lindblom A; Lockman J; Nilbert M; Senter L; Sotamaa K; de la Chapelle A. "Long-range PCR facilitates the identification of PMS2-specific mutations.." Human Mutation. Vol. 27, no. 5. (May 2006.): 490

Gururangan S, Frankel W, Broaddus R, Clendenning M, Senter L, McDonald M, Eastwood J, Reardon D, Vredenburgh J, Quinn J, and Friedman H. "Multi-focal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS-2 mutation." Neuro-Oncology. (January 2007.)

Senter, L. and Chun, N.. "Genetic testing: applying scientific discovery to clinical practice." Community Oncology. Vol. 5, no. 12. (December 2008.): 660-664

Jackson C, Holter S, Pollett A, de la Chapelle A, Clendenning M, Chou S, Senter L, Ramphal R, Gallinger S, Boycott K. "Café-au-lait macules and pediatric malignancy with recessively inherited mutations in the DNA mismatch repair (MMR) gene PMS2: Case report and review of the literature." Pediatric Blood and Cancer. no. 50. (January 2008.): 1268-1270

Senter,Leigha; Clendenning,Mark; Sotamaa,Kaisa; Hampel,Heather; Green,Jane; Potter,John,D; Lindblom,Annika; Lagerstedt,Kristina; Thibodeau,Stephen,N; Lindor,Noralane,M; Young,Joanne; Winship,Ingrid; Dowty,James,G; White,Darren,M; Hopper,John,L; Baglietto,Laura; Jenkins,Mark,A; de la Chaple,Albert. "The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations." GASTROENTEROLOGY. Vol. 135, no. 2. (August 2008.): 419-428

Senter L, Clendenning M, Sotamaa K, Hampel H, Green J, Potter J, Lindblom A, Lagerstedt K, Thibodeau S, Lindor N, Young J, Winship I, Dowty J, White D, Hopper J, Baglietto L, Jenkins M, de la Chapelle A.. "The clinical phenotype of Lynch syndrome due to germline PMS2 mutations." Gastroenterology. no. 135. (January 2008.): 419-428

Kelly, K., Senter, L., Leventhal, H., Ozakinci, G., Porter, K.. "Subjective and objective risk of ovarian cancer in women at risk to carry mutations in BRCA1 and BRCA2.." Patient Education and Counseling. no. 70. (January 2008.): 135-142

Clendenning M, Senter L, Hampel H, Lagerstedt Robinson K, Sun S, Buchanan D, Walsh M, Nilbert M, Green J, Potter J, Lindblom A, de la Chapelle A. "A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome.." Journal of Medical Genetics. no. 45. (January 2008.): 340-345

Zighelboim I, Powell MA, Babb SA, Whelan AJ, Schmidt AP, Clendenning M, Senter L, Thibodeau SN, de la Chapelle A, Goodfellow PJ.. "Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch Syndrome." Familial Cancer. Vol. 4, no. 8. (January 2009.): 501-504

Senter, L and Friedman, S. "Mixed Blessings: Genetic Counselor Perspective." Community Oncology. Vol. 6, no. 1. (January 2009.): 46-48

Vahteristo, P; Koski, TA; Naatsaari, L; Kiuru, M; Karhu, A; Herva, R; Sallinen, SL; Vierimaa, O; Bjorck, E; Richard, S; Gardie, B; Bessis, D; Van Glabeke, E; Blanco, I; Houlston, R; Senter, L; Hietala, M; Aittomaki, K; Aaltonen, LA; Launonen, V; Lehtonen, R. "No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome." FAMILIAL CANCER. Vol. 9, no. 2. (June 2010.): 245-251

Weissman S, Burt R, Church J, Erdman S, Hampel H, Holter S, Jasperson K, Kalady M, Haidle J, Lynch H, Palaniappan S, Wise P, Senter L. "NSGC Practice Guidelines for the Genetics Management of Lynch Syndrome." Journal of Genetic Counseling. (December 2011.)

Riley B, Culver J, Skrzynia C, Senter L, Peters J, Costalas J, Callif-Daley F, Grumet S, Hunt K, Nagy R, McKinnon W, Petrucelli N, Bennett R, Trepanier A. "Essential Elements of Genetic Cancer Risk Assessment, Counseling, and Testing: Updated Recommendations of the National Society of Genetic Counselors." Journal of Genetic Counseling. (December 2011.)

McGee J, Kotsopoulos J, Lubinski J, Lynch H, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes W, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, and Narod SA. "Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers." Obesity. (January 2011.)

Mavaddat N, Barrowdale D, AndrulisIL, Domchek SM, Eccle D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O’Malley F, John EM, Janavicius R, Tihomirova L, O Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benítez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, HEBON, EMBRACE1, Peock S, Frost S, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schönbuchner I, Gevensleben H, GEMO Study Collaborators, Stoppa-Lyonnet D, Belotti M, Barjhoux L, Isaacs C, Peshkin BN, Caldes T, de al Hoya M, Cañadas C, Heikkinen T, Heikkilä P, Aittomäki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D’Andrea E, Yan M, Fox S, kConFab Investigators, Rebbeck TR Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, SWE-BRCA Collaborators, Steele L, Neuhausen SL, Nussbaum B, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC on behalf of the Consortium of Investigators of Modifiers of BR. "Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results for the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)." Epi, Biomarkers, and Prevention. (January 2011.)

Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, Lambrechts D, Despierre E, Barrowdale D, McGuffog L, Healey S, Easton DF, Sinilnikova O, Benitez J, Garcia MJ, Neuhausen S, Gail MH, Hartge P, Peock S, Frost D, Evans G, Eeles R, Godwin AK, Daly MB, Kwong A, Ma ESK, Lazaro C, Blanco I, Montagna M, D’Andrea E, Nicoletto O, Johnatty SE, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Loud JT, Greene MH, Mai PL, Chetrit A, Lubin FC, Hirsh-Yechezkel G, Blendon G, Andrulis IL, Toland AE, Senter, L, Gore ME, Gourley C, Michie CO, Song H, Tyrer J, Whittemore AS, McGuire V, Sieh W, Kristoffersson U, Olsson H, Borg A, Levine DA, Steele L, Beattie MS, Chan S, Nussbaum RL, Moysich KB, Gross J, Cass I, Walsh C, Li AJ, Leuchter R, Gordon O, Garcia-Closas M, Gayther S, Chanock SJ, Antoniou AC, and Pharoah PDP. "Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer." JAMA. (January 2012.)

Bellcross CA; Bedrosian SR; Daniels E; Duquette D; Hampel H; Jasperson K; Joseph DA; Kaye C; Lubin I; Meyer LJ; Reyes M; Scheuner MT; Schully SD; Senter L; Stewart SL; St Pierre J; Westman J; Wise P; Yang VW; Khoury MJ. "Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.." Genetics In Medicine: Official Journal Of The American College Of Medical Genetics. Vol. 14, no. 1. (January 2012.): 152

Iqbal J, Ragone A, Lubinski J, Lynch HT, Moller P, Ghadirian P, Foulkes WD, Armel S, Eisen A, Neuhausen SL, Senter L, Singer CF, Ainsworth P, Kim-Sing C, Tung N, Friedman E, Llacuachaqui M, Ping S, Narod SA; Hereditary Breast Cancer Study Group.. "The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers." Br J Cancer. Vol. 107, no. 12. (December 2012.): 2005-2009

Allain D, Friedman S, Senter L.. "Consumer awareness and attitudes about insurance discrimination post enactment of the Genetic Information Nondiscrimination Act.." Fam Cancer. Vol. 11, no. 4. (December 2012.): 637-644

McGee J, Kotsopoulos J, Lubinski J, Lynch H, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes W, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, and Narod SA.. "Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers." Obesity. Vol. 20, no. 6. (June 2012.): 1288-1292

Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Neuhausen S, Demsky R, Foulkes W, Ghadirian P, Tung N, Ainsworth P, Senter L, Karlan B, Eisen A, Eng C, Weitzel J, Gilchrist D, Blum J, Zakalik, Singer , Fallen T, Ginsburgh O, Huzarski T, Sun P, and Narod SA.. "Oophorectomy after Menopause and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutations Carriers.." Cancer Epidemiology, Biomarkers, and Prevention. Vol. 21, no. 7. (July 2012.): 1089-1096.

Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, Lambrechts D, Despierre E, Barrowdale D, McGuffog L, Healey S, Easton DF, Sinilnikova O, Benitez J, Garcia MJ, Neuhausen S, Gail MH, Hartge P, Peock S, Frost D, Evans G, Eeles R, Godwin AK, Daly MB, Kwong A, Ma ESK, Lazaro C, Blanco I, Montagna M, D’Andrea E, Nicoletto O, Johnatty SE, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Loud JT, Greene MH, Mai PL, Chetrit A, Lubin FC, Hirsh-Yechezkel G, Blendon G, Andrulis IL, Toland AE, Senter, L, Gore ME, Gourley C, Michie CO, Song H, Tyrer J, Whittemore AS, McGuire V, Sieh W, Kristoffersson U, Olsson H, Borg A, Levine DA, Steele L, Beattie MS, Chan S, Nussbaum RL, Moysich KB, Gross J, Cass I, Walsh C, Li AJ, Leuchter R, Gordon O, Garcia-Closas M, Gayther S, Chanock SJ, Antoniou AC, and Pharoah PDP. "Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer." JAMA. Vol. 307, (January 2012.): 382-390

Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD, Ghadirian P, Neuhausen SL, Demsky R, Tung N, Ainsworth P, Senter L, Eisen A, Eng C, Singer C, Ginsburg O, Blum J, Huzarski T, Poll A, Sun P, Narod SA; the Hereditary Breast Cancer Clinical Study group.. "Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers." Breast Cancer Res. Vol. 14, no. 2. (March 2012.): R42-

Tomsic J, Senter L, Liyanarachchi S, Clendenning M, Vaughn CP, Jenkins MA, Hopper JL, Young J, Samowitz W, de la Chapelle A.. "Recurrent and founder mutations in the PMS2 gene." Clin Genet. Vol. 83, no. 3. (March 2013.): 238-43

Semple J, Metcalfe KA, Lynch HT, Kim-Sing C, Senter L, Pal T, Ainsworth P, Lubinski J, Tung N, Eng C, Gilchrist D, Blum J, Neuhausen SL, Singer CF, Ghadirian P, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.. "International rates of breast cancer reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers.." Ann Surg Onc. Vol. 20, no. 12. (November 2013.): 3817-3822

Segev Y, Iqbal J, Lubinski J, Gronwald J, Lynch HT, Moller P, Ghadirian P, Rosen B, Tung N, Kim-Sing C, Foulkes WD, Neuhausen SL, Senter L, Singer CF, Karlan B, Ping S, Narod SA; Hereditary Breast Cancer Study Group.. "The incidence of endometrial cancer in women with BRCA1 and BRCA2 mutations: an international prospective cohort study.." Gynecol Oncol. Vol. 130, no. 1. (July 2013.): 127-131

Mendler JH, Maharry KH, Becker H, Eisfeld AK, Senter L, Mrozek K, Kohschmidt J, Metzeler KH, Schwind S, Whitman SP, Khalife J, Caligiuri MA, Klisovic RB, Moore JO, Carter TH, Marcucci G, Bloomfield CD.. "In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline.." Haematoligica. Vol. 98, no. 8. (August 2013.): e92-e94

Hertlein E, Beckwith KA, Lozanski G, Chen TL, Towns WH, Johnson AJ, Lehman A, Ruppert AS, Bolon B, Andritsos L, Lozanski A, Rassenti L, Zhao W, Jarvinen TM, Senter L, Croce CM, Symer DE, de la Chapelle A, Heerema NA, Byrd JC.. "Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease.." PLoS One. 2013 Oct. 9;8(10).. Vol. 8, no. 10. (October 2013.): e76607

Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J, Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, Lee A, Bacot F, Vincent D, Hogervorst FBL, Peock S, Stoppa-Lyonnet D, Jakubowska A, kConFab Investigators, Radice P, Schmutzler RK, SWE-BRCA, Domchek SM, Piedmonte M, Singer CF, Friedman E, Thomassen M, Ontario Cancer Genetics Network, Hansen TVO, Neuhausen SL, Szabo CI, Blanco I, Greene MH, Karlan BY, Garber J, Phelan CM, Weitzel JN, Montagna M, Olah E, Andrulis IL, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Nevanlinna H, Osorio A, Terry MB, Daly MB, van Rensburg EJ, Hamann U, Ramus SJ, Toland AE, Caligo MA, Olopade OI, Tung N, Claes K, Beattie MS, Southey MC, Imyanitov EN, Tischkowitz M, Janavicius R, John EM, Kwong A, Diez O, Balman˜ a J, Barkardottir RB, Arun BK, Rennert G, Teo SH, Ganz PA, Campbell I, van der Hout AH, van Deurzen CHM, Seynaeve C, Go´mez Garcia EB, van Leeuwen FE, Meijers-Heijboer HEJ, Gille JJP, Ausems MGEM, Blok MJ, Ligtenberg MJL, Rookus MA, Devilee P, Verhoef S, van Os TAM, Wijnen JT, HEBON, EMBRACE, Frost D, Ellis S, Fineberg E, Platte R, Evans DG, Izatt L, Eeles RA, Adlard J, Eccles DM, Cook J, Brewer C, Douglas F, Hodgson S, Morrison PJ, Side LE, Donaldson A, Houghton C, Rogers MT, Dorkins H, Eason J, Gregory H, McCann E, Murray A, Calenders A, Hardouin A, Berthet P, Delnatte C, Nogues C, Lasset C, Houdayer C, Leroux D, Rouleau E, Prieur F, Damiola F, Sobol H, Coupier I, Venat-Bouvet L, Castera L, Gauthier-Villars M, Le´one´ M, Pujol P, Mazoyer S, Bignon Y, GEMO Study Collaborators, Złowocka-Perłowska E, Gronwald J, Lubinski J, Durda K, Jaworska K, Huzarski T, Spurdle AB, Viel A, Peissel B, Bonanni B, Melloni G, Ottini L, Papi L, Varesco L, Tibiletti MG, Peterlongo P, Volorio S, Manoukian S, Pensotti V, Arnold N, Engel C, Deissler H, Gadzicki D, Gehrig A, Kast K, Rhiem K, Meindl A, Niederacher D, Ditsch N, Plendl H, Preisler-Adams S, Engert S, Sutter C, Varon-Mate. "Genome-wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk. PLOS Genetics March 2013; 9(3): 1-21.." PLOS Genetics. Vol. 9, no. 3. (March 2013.): 1-21

Valentini A, Lubinski J, Byrski T, Ghadirian P, Moller P, Lynch HT, Ainsworth P, Neuhausen SL, Weitzel J, Singer CF, Olopade OI, Saal H, Lyonnet DS, Foulkes WD, Kim-Sing C, Manoukian S, Zakalik D, Armel S, Senter L, Eng C, Grunfeld E, Chiarelli AM, Poll A, Sun P, Narod SA; The Hereditary Breast Cancer Clinical Study Group.. "The impact of pregnancy of breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.." Breast Cancer Res Treat. Vol. 142, no. 1. (November 2013.): 177-185

Giannakeas V, Lubinski J, Gronwald J, Moller P, Armel S, Lynch HT, Foulkes WD, Kim-Sing C, Singer C, Neuhausen SL, Friedman E, Tung N, Senter L, Sun P, Narod SA.. "Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a prospective study.." Breast Cancer Res Treat. Vol. 147, no. 1. (August 2014.): 113-118

Kotsopoulos J, Lubinski J, Moller P, Lynch HT, Singer CF, Eng C, Neuhausen SL, Karlan B, Kim-Sing C, Huzarski T, Gronwald J, McCuaig J, Senter L, Tung N, Ghadirian P, Eisen A, Gilchrist D, Blum JL, Zakalik D, Pal T, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.. "Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers.." Breast Cancer Res Treat. Vol. 143, no. 3. (February 2014.): 579-586

Shen TK, Teknos TN, Toland AE, Senter L, Nagy R.. "Salivary Gland Cancer in BRCA-Positive Families : A Retrospective Review.." JAMA Otolaryngol Head Neck Surg. Vol. epub, (September 2014.): epub

Senter L, O’Connor M, Oriyo F, Sweet K, Toland AE.. "Linking distant relatives with BRCA gene mutations: potential for cost savings.." Clinical Genetics. Vol. 85, no. 1. (January 2014.): 54-58

Phelan CM, Iqbal J, Lynch HT, Lubinski J, Gronwald J, Moller P, Ghadirian P, Foulkes WD, Armel S, Eisen A, Neuhausen SL, Senter L, Singer CF, Ainsworth P, Kim-Sing C, Tung N, Llacuachaqui M, Chornokur G, Ping S, Narod SA; Hereditary Breast Cancer Study Group.. "Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study.." Br J Cancer. Vol. 110, no. 2. (January 2014.): 530-534

Finch AP, Lubinski J, Møller P, Singer CF, Karlan B, Senter L, Rosen B, Maehle L, Ghadirian P, Cybulski C, Huzarski T, Eisen A, Foulkes WD, Kim-Sing C, Ainsworth P, Tung N, Lynch HT, Neuhausen S, Metcalfe KA, Thompson I, Murphy J, Sun P, Narod SA.. "Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation." J Clin Oncol. Vol. 32, no. 15. (May 2014.): 1547-1553

Kotsopoulos J, Lubinski J, Gronwald J, Cybulski C, Demsky R, Neuhausen SL, Kim-Sing C, Tung N, Friedman S, Senter L, Weitzel J, Karlan B, Moller P, Sun P, Narod SA; the Hereditary Breast Cancer Clinical Study Group.. "Factors influencing ovulation and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.." Int J Cancer. Vol. epub, (December 2014.): epub

Gronwald J, Robidoux A, Kim-Sing C, Tung N, Lynch HT, Foulkes WD, Manoukian S, Ainsworth P, Neuhausen SL, Demsky R, Eisen A, Singer CF, Saal H, Senter L, Eng C, Weitzel J, Moller P, Gilchrist DM, Olopade O, Ginsburg O, Sun P, Huzarski T, Lubinski J, Narod SA; Hereditary Breast Cancer Clinical Study Group.. "Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers.." Breast Cancer Res Treat. Vol. 146, no. 2. (July 2014.): 421-427

Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL; CIMBA Consortium, Laitman Y, Kushnir A, Paluch-Shimon S, Berger R, Zidan J, Friedman E, Ehrencrona H, Stenmark-Askmalm M, Einbeigi Z, Loman N, Harbst K, Rantala J, Melin B, Huo D, Olopade OI, Seldon J, Ganz PA, Nussbaum RL, Chan SB, Odunsi K, Gayther SA, Domchek SM, Arun BK, Lu KH, Mitchell G, Karlan BY, Walsh C, Lester J, Godwin AK, Pathak H, Ross E, Daly MB, Whittemore AS, John EM, Miron A, Terry MB, Chung WK, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Steele L, Neuhausen SL, Ding YC, Ejlertsen B, Gerdes AM, Hansen Tv, Ramón y Cajal T, Osorio A, Benitez J, Godino J, Tejada MI, Duran M, Weitzel JN, Bobolis KA, Sand SR, Fontaine A, Savarese A, Pasini B, Peissel B, Bonanni B, Zaffaroni D, Vignolo-Lutati F, Scuvera G, Giannini G, Bernard L, Genuardi M, Radice P, Dolcetti R, Manoukian S, Pensotti V, Gismondi V, Yannoukakos D, Fostira F, Garber J, Torres D, Rashid MU, Hamann U, Peock S, Frost D, Platte R, Evans DG, Eeles R, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Izatt L, Adlard J, Donaldson A, Ellis S, Sharma P, Schmutzler RK, Wappenschmidt B, Becker A, Rhiem K, Hahnen E, Engel C, Meindl A, Engert S, Ditsch N, Arnold N, Plendl HJ, Mundhenke C, Niederacher D, Fleisch M, Sutter C, Bartram CR, Dikow N, Wang-Gohrke S, Gadzicki D, Steinemann D, Kast K, Beer M, Varon-Mateeva R, Gehrig A, Weber BH, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Houdayer C, Belotti M, Gauthier-Villars M, Damiola F, Boutry-Kryza N, Lasset C, Sobol H, Peyrat JP, Muller D, Fricker JP, Collonge-Rame MA, Mortemousque I, Nogues C, Rouleau E, Isaacs C, De Paepe A, Poppe B, Claes K, De Leeneer K, Piedmonte M, Rodriguez G, Wakely K, Boggess J, Blank SV, Basil J, Azodi M, Phillips KA, Caldes T, de la Hoya M, Romero A, Nevanlinna H, Aittomäki K, van der Hout AH, Ho. "Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.." JAMA. Vol. 313, no. 13. (April 2015.): 1347-1361

Kämpjärvi K, Järvinen TM, Heikkinen T, Ruppert AS, Senter L, Hoag KW, Dufva O, Kontro M, Rassenti L, Hertlein E, Kipps TJ, Porkka K, Byrd JC, de la Chapelle A, Vahteristo P.. "Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia.." Oncotarget. Vol. 6, no. 3. (January 2015.): 1884-1888

Goodenberger ML, Thomas BC, Riegert-Johnson D, Boland CR, Plon SE, Clendenning M, Win AK, Senter L, Lipkin SM, Stadler ZK, Macrae FA, Lynch HT, Weitzel JN, de la Chapelle A, Syngal S, Lynch P, Parry S, Jenkins MA, Gallinger S, Holter S, Aronson M, Newcomb PA, Burnett T, Le Marchand L, Pichurin P, Hampel H, Terdiman JP, Lu KH, Thibodeau S, Lindor NM.. "PMS2 monoallelic mutation carriers: the known unknown.." Genet Med.. Vol. epub, (April 2015.): epub

Cybulski C, Lubinski J, Huzarski T, Lynch HT, Randall SA, Neuhausen SL, Senter L, Friedman S, Ainsworth P, Singer C, Foulkes WD, Narod SA, Sun P, Kotsopoulos J.. "Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.." Breast Cancer Res Treat. Vol. epub, (May 2015.): epub

Reference Works


January 2011:
  • Pamarti AK, Lerner B, Roche P, Senter L.."Genetics Information Nondiscrimination Act (GINA) and Its Affect on Genetic Counseling Practice: A Survey of Genetic Counselors"
  • Jarvinen TM, Liyanarachchi S, Comeras I, Senter L, Lozanski G, Hertlein E, Byrd JC, de la Chapelle A.."Linkage study suggests common genetic determinants for chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis"
January 2010: 
  • Senter L, Sweet K, Gnanadesikan S, Newman D, Toland AE."VUS Predict: a web-based tool for classifying BRCA variants of uncertain significance" Washington DC
  • Senter L, Sweet K, Gnanadesikan S, Newman D, Toland AE."VUS Predict: a web-based toll for classifying BRCA variants of uncertain significance" Dallas
January 2008:
  • L Senter, M Clendenning, S Sun, J Panescu, S Gallinger, J Mackay, J Larsen Haidle, M Greenblatt, J Young, A de la Chapelle.."Founder Mutations in PMS2."
January 2007:
  • Senter L, Clendenning M, Hampel H, Sotamaa K, de la Chapelle A.."Clinical phenotype of individuals with germline mutations in the PMS2 gene." . : 31
  • Boycott KM, Jackson C-C, Chou S, Ramphal R, Pollett A, Holter S, Senter L, Clendenning M, Gallinger S.."Cafe-au-lait macules and malignancy with recessively inherited mutations in DNA mismatch repair (MMR) genes: Case report and review of the literature." . : 72
  • S Holter, A Pollett, G Zogopoulos, H Kim, K Boycott, CC Jackson, S Chou, L Senter, M Clendenning, A de la Chapelle, S Gallinger.."Hepatic Adenomas caused by TCF1 Mutations in Patients with Biallelic Germline Mismatch Repair Gene Mutations" 
  • Senter L, Stephens J, Agnese D."Predictors of progression to malignancy or BI-RADS 4: Can we determine what BI-RADS 3 lesions should be biopsied?"








Presentations

"PMS2: Differences between monoallelic and biallelic mutation carriers." Presented at National Society of Genetic Counselors Annual Education Conference, Los Angeles, CA, US|USA. (October 2008)

"Hot Topics: Clinical Sciences." Presented at Collaborative Group of the Americas-Inherited Colorectal Cancer (CGA-ICC) Annual Meeting, Honolulu, HI, US|USA. (October 2009)

"GINA: Process and Implications." Presented at American Society of Human Genetics Annual Meeting, Honolulu, HI, US|USA. (October 2009)

"Cancer Family History: Basics." Presented at National Society of Genetic Counselors Online Course, (July 2010)

"Implementing IHC at Your Insitution." Presented at Collaborative Group of the Americas-Inherited Colorectal Cancer Annual Meeting, Dallas, TX, US|USA. (November 2010)

"GINA: The Process and Implications." Presented at National Society of Genetic Counselors Annual Education Conference, Dallas, TX, US|USA. (November 2010)
Advising

Advising

Academic Advisees

2011:

  • OSU CSE758, The Ohio State University, Breast Cancer Risk Program
2010-2011:
  • Abhilasha Pamarti, Brandeis University, Genetic Information Nondiscrimination Act (GINA) and its Affect on Genetic Counseling Practice: A Survey of Genetic Counselors
2009-2010:
  • Amy Garrison, Sarah Lawrence College – Graduated 2010, Consumer Knowledge of GINA

Contact

Division of Human Genetics

Amy Ehrlich
Division Administrator
Amy.Ehrlich@osumc.edu
Phone: 614-293-7775
Fax: 614-293-2314

Division’s office:
2012 Kenny Rd. Rm. 250
Columbus, OH 43221

Schedule an appointment: 614-293-6694