When a patient presents with truly asymptomatic hypereosinophilia without end organ manifestations, it is difficult to know when and if therapy should be initiated. In one study, the patients included had had asymptomatic HE for >5 years and none progressed. In a separate study, at least one progressed, although the inclusion criteria were less clear and many were treated with glucocorticoids. The goal of this study is to assess clinical signs and symptoms and objective measures to provide guidance to clinicians regarding the need for intervention in patients with asymptomatic eosinophilia.

While assessment and treatment of chronic rhinosinusitis has historically been based on clinical features, emerging data has shown that even with similar clinical presentations, patients may have distinct molecular endotypes. These endotypes have shown variable responses to medical therapy and surgical interventions, and better understanding of these groups will likely lead to better personalized care and improved outcomes to treatment. The purpose of this study is to better characterize molecular endotypes of chronic rhinosinusitis in our patient population via tissue and serologic studies.

Shepherd MW, Curtis CD, Phillips G, Ogbogu PU. Atopic characteristics of patients with vocal cord dysfunction. Ann Allergy Asthma Immun. 2017:118(2):228-230.

Curtis CD, section editor, Asthma. In: ACAAI Review for the Allergy & Immunology Boards, Third edition.

Curtis CD, Ogbogu PU. Hypereosinophilic Syndrome. Clin Rev Allergy Immunol. 2016:50(2):240-251.

Curtis CD, Ogbogu PU. Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia. Immunol Allergy Clin North Am. 2015:35(3)387-402.

Curtis CD, Fox CC. Treatment of adult hyper-IgD syndrome with canakinumab. J Allergy Clin Immunol Pract. 2015:3(5):817-818.

Curtis CD, Stukus DR, Scherzer R. Epinephrine preparedness in pediatric food allergic patients: an ideal time for change. Ann All Asthma Immunol. 2014;112(6):560-562.  

 

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