Improving patient outcomes through research

The Division of Pulmonary, Critical Care and Sleep Medicine is dedicated to gaining new knowledge about disease so we can improve the quality of life of our patients. We have a growing program in clinical research and we are actively recruiting people to participate in one of our clinical trials. We have trials centered on both outpatient (clinic) and inpatient (ICU) locations.

Clinical and Basic Science Research

Clinical research not only generates new knowledge but also allows us to offer patients the opportunity to receive new cutting edge therapies and most importantly, extensive one-on-one education. Our patients have expressed a high degree of satisfaction after participating in our trials and cite the educational benefits as the best part of the experience. We also have a robust basic science research program spanning several areas of cutting edge investigation. Airways Disease Research

Airways Disease Research

Our Airway Disease Research Program centers on translational research in the following areas with the goals of improving the lives of patients with airway diseases and understanding the basic mechanisms of these diseases to further advance the efforts for a cure:
  • COPD
  • Asthma
  • Cystic fibrosis
  • Bronchiolitis
  • Sarcoidosis
Our research includes studies on both the individual disease process and on underlying mechanisms they may have in common. We have a clinical research focus on promoting both pharmacologic and non-pharmacologic disease interventions.

Multi-Center Clinical Research

Our centers participate in several national multi-center clinical research networks which conduct large simple clinical and translational research trials. Our airways disorders team also collaborates with several basic science labs centered on investigating the underlying inflammatory host response among airway diseases.

We are also active in testing novel treatments, such as exercise therapy, based on individual patient characteristics such as smoking status, HIV status, environmental allergies, age, gender and race, among others.

Personalized Healthcare Collaborations

We fully embrace The Ohio State University Wexner Medical Center’s commitment to personalized healthcare and translation of research findings to the Lung Center. We are active in the NIH sponsored Research Match program, which allows patients to volunteer for research studies.

In addition to our national network partners, we collaborate with investigators at OSU from the departments of:

  • Dentistry
  • Pharmacology
  • Informatics
  • Public Health
  • Veterinary Medicine
  • Neurosurgery
  • Sports Medicine
  • Otolaryngology
  • Immunology
  • Psychiatry

We also have active collaborative relationships with investigators based at Nationwide Children’s Hospital and interact with our medical center's signature programs in critical care and cancer.

Critical Care Research

Critical Care Research

Critical care research in our division is focused around sepsis and sepsis-associated organ dysfunction.


Sepsis is a systemic response to infection or injury which kills over 200,000 Americans a year. Research on the pathogenesis of sepsis includes investigations into basic mechanisms of inflammation, innate immunity, mitochondrial dysfunction and host-pathogen interactions.

There is also a strong interest in individual differences leading from uncomplicated infections to sepsis.

Translational Research

Translational efforts focus on studying these basic discoveries in septic patients and characterizing the role of patient factors, such as smoking and nutritional status.

Clinical Research

Clinical research focuses on developing novel therapies for sepsis-related organ failure, especially lung failure, called acute lung injury and acute respiratory distress syndrome (ALI/ARDS) and neuromuscular consequences of sepsis, including delirium and ICU-acquired weakness.

Multi-Center Studies Exploring Novel Strategies and Treatments

We are or have been involved in multi-center studies exploring novel strategies of mechanical ventilation and novel pharmacologic treatments for ALI/ARDS. We have also coordinated the largest study of ICU-acquired weakness and are pursuing a variety of possible treatments for these patients. Investigators are also focused on the national epidemiology of sepsis and sepsis-related death and the identification of previously unknown risk factors.

Finally, organizing care delivery for septic patients to provide appropriate care to all victims is a major emphasis of our clinical effectiveness research projects. This is bolstered by on-going screening, identification and data collection of all septic patients admitted to the ICU.