Innovations in cardiac surgery at Ohio State

The Department of Surgery's research efforts are focused on key areas of interest that promise to yield significant results in the understanding of disease and the improvement of clinical care.


Research Interests

Research plays an essential role in the advancement of cardiac surgery and in the never ending quest to improve the outcomes of cardiac surgery patients. Through research, we develop new procedures to treat ill patients and help patients live better, longer lives. The research activities of our division explore basic science by understanding and analyzing muscle biology and cell membrane repair.  Our team also excels in translational research with studies of resuscitation of lungs before transplant and also in clinical research, where we evaluate new and smaller ventricular assist devices and valves. We also have a strong clinical outcomes research group that evaluates the impact of delivery of care on cardiac surgery outcomes.

The division has also has a strong interest in training the next generation of cardiac surgeons. As such, we welcome medical students and residents to participate in our clinical and research activities.

Outcomes Research

“The Outcomes Center in the Division of Cardiac Surgery is designed to better understand and appreciate various factors that go into minimizing complications and improving patient outcomes. It is centered around gaining a deeper appreciation of the multiple factors that go into having successful surgical outcomes, including collaboration between research staff, nurses, coordinators, statisticians, epidemiologists, basic scientists and clinicians to foster a center of inquisitiveness and an ever constant push for improvements in the way we deliver care. As the director of the Outcomes Center, it is my hope that this collaboration fosters an environment conducive to researching new ideas and allows us the opportunity to teach each other to become better in our respective fields.”

-Bryan Whitson, MD, PhD
Outcomes Research Investigators

Outcomes Research Investigators

Basic and translational science investigators

Basic and translational science investigators

Clinical Trials

Clinical Trials

The Division of Cardiac Surgery at The Ohio State University Wexner Medical Center actively participates in numerous clinical trials. Committed faculty and dedicated team members we are working to develop the future of medicine now.

For more information on cardiac surgery clinical trials, please contact the Heart and Vascular Research Organization (HVRO) at or speak with your doctor at your next appointment.

We currently have clinical trials open in the following areas:

Acute Kidney Injury

A study to evaluate efficacy and safety of QPI-1002 for prevention of acute kidney injury following cardiac surgery

Aortic Valve or Mitral Valve Disease

View open clinical trials for aortic valve disease and mitral valve disease.

  • Neuroprotection in Patients Undergoing Aortic Valve Replacement
  • Rate Control Versus Rhythm Control for Postoperative Atrial Fibrillation
  • Prospective, Non-Randomized, Multicenter Clinical Evaluation of Edwards Pericardial Bioprostheses with a New Tissue Treatment Platform (COMMENCE)

Heart Transplant

View open clinical trials for heart transplantation.

  • Outcomes AlloMap Registry: The Long-Term Management and Outcomes of Heart Transplant Recipients with AlloMap Testing (OAR)
  • SUSTAIN-IT: Sustaining Quality of Life of the Aged: Heart Transplantation or Mechanical Support?

Lung Transplant

Novel Lung Trial: Normothermic Ex-Vivo Lung Perfusion (EVLP) as an Assessment of Extended/Marginal Donor Lungs for Transplant

Structural Heart Disease

View open clinical trials for structural heart disease.

  • REPRISE III: Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System-Randomized Clinical Evaluation
  • Clinical Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional MR (COAPT)
  • Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI)
  • Medtronic CoreValve U.S. Pivotal Trial
  • Medtronic CoreValve Continued Access Study (High Risk and Extreme Risk Patients)
  • Medtronic CoreValve U.S. Expanded Use Study

Ventricular Assist Device

View open clinical trials for ventricular assist devices.

  • Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)
  • MOMENTUM 3 Multi-Center Study of MagLev Technology in Patients Undergoing MCS Therapy with HeartMate 3
  • Syncardia 50cc Temporary Total Artificial Heart (TAH-t) as a Bridge to Transplant
  • SOPRANO: A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Macitentan in Patients with Pulmonary Hypertension after Left Ventricular Assist Device Implantation
  • Safety and Efficacy of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in LVAD Recipients