Family medicine research at the forefront


Advancement, opportunity and collaboration describe the research and scholarship efforts in The Ohio State University Department of Family Medicine. Our faculty members are engaged in a broad range of multidisciplinary efforts to bolster advances in the practice, teaching and research of family medicine. Our successes are demonstrated by professional presentations, publications and grant support.

Our faculty's involvement in clinical research through the Central Ohio Practice-Based Research Network (OSU-COPBRN) promises to advance knowledge about many aspects of primary care – for example, chronic obstructive pulmonary disease, seasonal affective disorder, diabetes, etc. The OSU-COPBRN, which consists of 21 primary care sites – eight family medicine sites of The Ohio State University Primary Care Network, including one shared site with general internal medicine, five Ohio State University Division of General Internal Medicine sites and eight PrimaryOne Health, Inc. sites.

Investigator-initiated research drives the department toward its goal of being a nationally and internationally recognized leader in research and scholarship. Educational initiatives and research continue to produce state-of-the-art curriculum, teaching strategies and learning techniques that advance medical education at many levels including medical student education, residency training and continuing medical education.

Extramurally-funded active projects

Extramurally-funded active projects

Expanding, Enhancing and Enriching the Primary Care Workforce through Clinical Transformation Education

PI: Mary Jo Welker, MD

This is a five-year Primary Care Training and Enhancement grant (2016 - 2021) funded for $2,574,066 by the U.S. Department of Health and Human Services through the Bureau of Health Workforce of the Health Resources and Services Administration (HRSA). The purpose of this collaborative project is to further enhance the leadership roles of the Department of Family Medicine (lead applicant training program) and the College of Nursing (partnering collaborative training program) through continued development and implementation of innovative education and training initiatives designed to assure an enlarged primary care provider workforce well-prepared to practice in and lead transforming health care delivery systems. The objectives are:

  • To develop, implement and evaluate a four-year primary care interest (PCI) component of The Ohio State University College of Medicine Lead.Serve.Inspire curriculum
  • To develop, implement and evaluate a three-year focused primary care track (PCT) of The Ohio State University College of Medicine Lead.Serve.Inspire curriculum
  • To refine, expand and extend clinical transformation education to all medical students, nursing students and other health professional students at The Ohio State University
  • To develop, implement and evaluate a healthcare transformation and leadership training curriculum for family medicine resident physicians in The Ohio State University Family Medicine Residency Program
  • To provide evidence-based training in opioid use disorder (OUD) prevention, diagnosis and treatment, emphasizing medication-assisted treatment (MAT) to primary care providers and other healthcare professionals to assure an interprofessional work force prepared to address the opioid epidemic

Yoga for Restless Legs Syndrome, a Common and Burdensome Sleep Disorder

Sponsor: West Virginia University (WVU) sub-award/National Center for Complementary and Integrative Health (NCCIH) prime award
Subaward PI: Maryanna Klatt, PhD
Dates: 9/1/17-8/31/18
Award: $33,272
Objectives: The primary goal is to assess, in adults with symptomatic RLS, the acceptability and feasibility of a 12-week RCT comparing yoga to an attention control. We will evaluate 1) rates of screening, recruitment and randomization to determine optimal strategies; and 2) retention, adherence and satisfaction to determine feasibility and acceptability of the 12-week yoga and educational film programs. Our secondary objectives include the assessment of treatment fidelity in the two programs, as well as participant willingness to enroll in yoga programs of varying duration and intensity. In addition, we will measure RLS symptom severity, sleep quality, mood and health-related quality of life at baseline and 12 weeks to obtain effect size estimates for these exploratory outcomes. This information will provide critical data on which to base our planned larger RCT to determine the efficacy of yoga as a potential therapy for RLS.

Implementing a Series of Micro and Macro-Ergonomic Interventions to Reduce Work-Related Musculoskeletal Disorders

Sponsor: Ohio Bureau of Workers Compensation (BWC)
Co-I: Maryanna Klatt, PhD (PI: Kevin Evans, PhD)
Dates: 6/1/17-5/31/19
Award: $250,000
Objectives: The primary goal is to reduce musculoskeletal injuries and discomfort in radiologic technologists and radiation therapy technologists through a proactive, context-specific intervention designed to be administered while the technologists are still in training and which they can continue to use entering the profession.

Urine Antimicrobial Proteins in Older Adults: Aging, Infection & Innate Immunity

Sponsor: National Institute of Aging (NIA)
Co-I: Randy Wexler, MD (PI: Jeffrey Caterino, MD)
Dates: 6/1/16-5/31/21
Award: $2,805,735
Objectives: The primary goal is to identify and measure changes in baseline urinary AMP levels associated with aging and to create a normal distribution parameter of AMPs for an uninfected older cohort. The primary quantitative outcome will examine the association between age (<65 or ≥65) and the measurable levels of AMPs. Also, this outcome will include a comparison of the proportion of subjects with non-measurable levels of each AMP between the ages of <65 and ≥65.

Translational Candidate-Gene Studies of Simvastatin-Induced Myopathy in African Americans

Sponsor: National Institute on Minority Health and Health Disparities (NIMHD)
Co-I: Leon McDougle, MD (PI: Joseph Kitzmiller, MD, PhD)
Dates: 9/24/17-4/30/22
Award: $1,889,690
Objectives: The primary goal of pharmacogenomic research is to improve the understanding of how genetic factors influence individual patient response to medication. A cornerstone of precision medicine, pharmacogenomics testing is used clinically to help prescribers select appropriate medications and doses to improve the efficacy and cost-effectiveness (as well as reducing adverse effects) of pharmacotherapies. The pharmacogenomics research supported by this grant aims to improve pharmacotherapy outcomes in African Americans – a large minority health disparity population.

Ohio Cardiovascular Disease Best Practices Network

Sponsor: Case Western Reserve University (CWRU) sub-award/Ohio Department of Medicaid (ODM) prime award
Subaward PI: Randy Wexler, MD
Dates: 10/4/17-6/30/19
Award: $244,637
Objectives: The primary goal of this project is to implement the MEDTAPP Ohio Cardiovascular Disease Best Practices Network (CVD BPN). Recognizing the need to enhance the skills of current health professionals, this project will prepare current Medicaid providers to address the social determinants of health and improve health outcomes for the Medicaid population, specific to those patients who are at risk or have been diagnosed with hypertension and other cardiovascular diseases.

Ohio Equity Institute (OEI) Evaluation

Sponsor: Ohio Department of Medicaid/Government Resource Center
PI: Huerta, TR
Co-I's: McAlearney, AS; Sieck, CJ; Hefner, J; Walker, D; Hogan, TH; Swoboda, C
Dates: 2/2018-7/2019
Competitive contract: $1,366,022
Objectives: The overall goal of this evaluation effort is to examine the extent to which newly implemented programs (centering pregnancy, home visiting, and community health workers) serve high-risk Medicaid enrolled pregnant women and to assess the effect of these interventions on health care utilization and birth outcomes.

Infant Mortality Research Partnership, Phase 2 (IMRP2)

Sponsor: Ohio Department of Medicaid 
PI: Gabbe, S
Co-I's: Huerta, TR; Hebert, C; Lemeshow S
Dates: 11/2017-6/2018
Competitive grant: $206,433
Objectives: This project will evaluate multiple programs aiming to improve birth outcomes and reduce racial disparities in infant deaths across nine Ohio counties. Specifically we will oversee the collection and evaluation of data related processes and outcomes of note, including health care utilization, family planning and births.

Searching for Management Approaches to Reduce HAI Transmission (SMART)

Sponsor: Agency for Healthcare Research and Quality 
PI: McAlearney, AS
Co-I's: Huerta, TR; Sieck, C; Hefner, J; Hebert C
Dates: 4/2017-3/2021
Competitive grant: $1,887,609
Objective: The project is designed to identify the organizational and structural practices that are associated with better performance at reducing and preventing healthcare-associated infections (HAIs). This five-year project is focused on central line-associated blood stream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) and involves both intensive care units (ICUs) and medical/surgical units. We aim to create a generalizable management practice toolkit that can then be leveraged in the improvement of other HAI outcomes.

Development and Evaluation of Socio-Technical Metrics to Inform HIT Adaptation

Sponsor: Agency for Healthcare Research and Quality
PI: Yen, PY
Co-I's: McAlearney, AS; Huerta, TR; Sieck, C; Hefner, J
Dates: 7/2016-6/2018
Competitive grant: $300,000
Objectives: The goal of this project is to identify measures and create instruments to evaluate the progress of health information technology (HIT) adaptation.

High Touch and High Tech (HT2): Transforming Patient Engagement Throughout the Continuum of Care by Engaging Patients with Portal Technology at the Bedside

Sponsor: Agency for Healthcare Research and Quality (R-01)
PI: McAlearney, AS
Co-I's: Huerta, TR; Sieck, C; Moffatt-Bruce, S; Hefner, J; Johansen, M; Wallace, L; Rizer MK
Dates: 9/2015-8/2019
Competitive grant: $973,109
Objectives: This project examines how inpatient portals impact the inpatient stay. Our team is specifically interested in how training affects a patient’s engagement with the portal, as well as how the portal changes communication pathways between patients and providers.

Patient Safety Learning Laboratories: Information for the Design of Environments Aligned for Patient Safety (IDEA4PS)

Sponsor: Agency for Healthcare Research and Quality (P-30)
PI: Moffatt-Bruce, S
Project director: McAlearney, AS
Co-PD: Huerta, TR
Dates: 9/2015-8/2019
Competitive grant: $3,963,276
Objectives: The Institute for the Development of Environments Aligned for Patient Safety (IDEA4PS) seeks to use system approaches to bring together multidisciplinary teams to generate new ways of looking at information and data aimed at improving patient safety. Twenty-three investigators from The Ohio State University Wexner Medical Center (OSUWMC) and beyond are participating in this Patient Safety Learning Laboratory, proving how the university is truly working together for patient safety.

Taxonomy for Patient-Centered Outcomes Research

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)
Co-PI's: McAlearney, AS; Huerta, TR
Co-I's: Sieck, CJ; Hefner, J; Aldrich, A
Dates: 1/2015-12/2018
Competitive contract: $744,412
Objectives: This project involves the development and application of a classification scheme (i.e., taxonomy) to describe the PCORI-funded portfolio to internal staff and external stakeholders. The taxonomy is intended to assist with answering descriptive questions about the composition of the portfolio, including trends that emerge over time. In addition to describing PCORI funding, the taxonomy is intended to support strategic decision-making related to PCORI funding, with a goal of funding research to improve the quality and relevance of evidence available to help patients, caregivers, providers, employers, insurers and policy-makers make informed health decisions.
Investigator-initiated research

Investigator-initiated research

Investigator-initiated research within Ohio State's Department of Family Medicine represents ongoing collaboration with other disciplines at the university as well as collaboration with outside institutions. Through this research, investigators are evaluating clinical interventions to enhance healthcare screening practices, health literacy, patient compliance with healthcare and communication between patients and providers in conditions such as cancer, hypertension and diabetes. The department's physician expertise and diverse patient population provides a rich environment for such research.

If you have questions about clinical research in the Department of Family Medicine, please contact Pamela Beavers: Pamela.Beavers@osumc.edu.  

Completed Clinical Research Studies

All study activity is completed.

Acceptance of Outpatient Electronic Medical Record by Physicians and Patients at The Ohio State University Medical Center During an Institution Wide Implementation
PI: Milisa Rizer, MD
Purpose: The purpose of this study was to assess physician and patient feedback regarding electronic medical record implementation at The Ohio State University Wexner Medical Center.

Americans in Motion – Healthy Interventions (AIM-HI)
PI: Perry Mostov, DO
Purpose: The Americans in Motion - Healthy Interventions (AIM-HI) study was designed to evaluate the impact of a fitness program, including healthy eating, physical activity and emotional health.

Assessing Cardiovascular Risk in a Family Practice Population
PI: W. Fred Miser, MD
Purpose: The primary purpose of this study was to validate a new cardiac risk tool for use in the family practice population. This tool was developed in line with the latest recommendations from the United States Preventive Services Task Force (USPSTF).

Clinical Utility of the Newest Vital Sign in Family Medicine: A Pilot Study

PI: Lorraine Wallace, PhD
Purpose: The aim of this study was to examine whether participant use of a calculator is associated with improved scores on the Newest Vital Sign, a screening tool to detect inadequate health literacy.

Clinical Utility of Spanish Language Health Literacy Measures
PI: Lorraine Wallace, PhD
Purpose: The aim of this study was to examine whether participant use of a calculator is associated with improved scores on a screening tool to detect inadequate health literacy and numeracy.

Cognitive Behavioral Therapy Techniques and Lifestyle Changes: Reducing Systolic Blood Pressure
PI: Randy Wexler, MD
Purpose: The aim of this study was to determine whether behavioral change to improve blood pressure control was greater in patients who used cognitive behavioral therapy techniques to support their health behavior change.

Core Stability, Biomechanical Joint Loading and Athletic Performance
PI: Ajit Chaudhair, PhD
Co-I: Tom Best, MD, PhD; Deborah Givens, PT, PhD; Greg Young, MS
Purpose: This randomized interventional study assessed the influence of improving core stability on reducing lower extremity joint loading and improving athletic performance in football athletes. Forty subjects were randomized into a core stability training group or a whole-body resistance training group for six weeks, with both pre- and post-testing of lower extremity biomechanics, performance in selected football-specific tasks and clinical strength measures.

Development and Validation of Educational Materials to Foster Safe Use of Opioid Medication
PI: Lorraine Wallace, PhD 
Purpose: The purpose of this study was to assess patient comprehension of the OxyContin Medication Guide (OxyMG) and Patient Medicine Information Sheet—Long Acting Opioids (PMIS).

Efficacy of Web-Based Physician Education
Site PI: Doug Post, PhD 
Purpose: The aim of this study was to change the skin examination practices of primary care physicians by developing the Basic Skin Cancer Triage Curriculum into a web-based course and to evaluate its efficacy in a geographically diverse sample of community-based primary care physicians.

Initial Development of the Opioid Health Activities Tool (OHAT): A Pilot Study
PI: Lorraine Wallace, PhD 
Purpose: The purpose of this study was to develop a valid and reliable Opioid Health Activities Tool (OHAT) to simulate tasks routinely required of patients prescribed opioids.

Medical Student Partners in Health
PI: Doug Post, PhD
Purpose: The purpose of this project is to develop and test the feasibility of an educational intervention delivered by first-year medical students to senior patients with uncontrolled type 2 diabetes who receive their health care in OSU primary care clinics.

Mindfulness-Based Approach to the Treatment of Obesity and Diabetes

PI: Carla Miller, PhD
Co-I: W. Fred Miser, MD
Purpose: The purpose of this project was to test the effects of a dietary intervention based on self-regulation and dietary intake on weight loss compared to a standard nutrition education curriculum.

Ohio Patient Navigator Research Program
PI: Electra Paskett, PhD
Co-I: Doug Post, PhD
Purpose: The Ohio Patient Navigator Research Program (OPNRP) is designed to alleviate disparities in relation to the timely diagnosis and treatment of breast, cervical and colorectal cancer in underserved populations in Columbus, Ohio.

Patient Centered Communication During Chemotherapy
PI: Doug Post, PhD
Purpose: This study was designed to evaluate communication between cancer patients and clinicians through the development and evaluation of a PDA-based patient communication intervention for breast cancer patients undergoing chemotherapy treatment. The intervention was comprised of two integrated components: symptom monitoring and tailored patient communication training.

Patient Centered Communication During Chemotherapy: A Focus Group Study in Appalachia
PI: Doug Post, PhD
Purpose: Focus groups were conducted to obtain patient and clinician feedback on the quality of a patient communication tool and its applicability to a patient population who reside in Appalachia, Ohio.

Patients' Ability to Complete the Newest Vital Sign
PI: Lorraine Wallace, PhD
Purpose: The aim of this study was to examine whether participant use of a calculator is associated with improved scores on Newest Vital Sign, a screening tool to detect inadequate health literacy.

Patients' Experiences Using Pain Medication

PI: Lorraine Wallace, PhD
Purpose: The aim of this study was to assess the validity and reliability of the Patient Opioid Knowledge and Activities Questionnaire (POKAQ).

Remote Home Blood Pressure Monitoring: A Feasibility Study
PI: Neeraj Tayal, MD
Co-I: Milisa Rizer, MD; Albert Lai, PhD; Stuart Beatty, PharmD
Purpose: The purpose of this project was to investigate the feasibility of using information technology (IT) to facilitate patient self-monitoring of blood pressure with conveyance of this information to a care team.

Risky Sexual Behavioral and Cervical Cancer in Rural Ohio Women
PI: Doug Post, PhD
Purpose: The overall goal of this project was to assess the feasibility of a behavioral intervention delivered by lay health advisers. Focus group members provided information that was used to understand community perceptions of the association between sexual behavior and cancer risk and reviewed models of the educational materials to be used in the later intervention phase of the study.

The Association of Health Literacy, Diabetes Knowledge and Glycemic Blood Pressure and Lipid Control in Patients with Diabetes Mellitus who Receive Their Care in a Family Practice Office
PI: W. Fred Miser, MD
Purpose: This study evaluated the relationship between health literacy, the ability to comprehend and use basic health information and knowledge about diabetes mellitus and lipid and blood pressure control among diabetic patients.

Urban Cardiovascular Diabetic F.I.T.N.E.S.S. Program: Fitness Improved Through Nutrition and Exercise Sustained by Support of Family, Friends and Community Partners
PI: Leon McDougle, MD
Purpose: This behavioral modification program aimed to enhance public health and social welfare by optimizing lifestyle change for urban African American type-2 diabetics, thereby decreasing disparities in healthcare outcomes for this population.

Using Photovoice to Chronicle the Daily Experience of Primary Care Patients with Chronic Pain

PI: Lorraine Wallace, PhD 
Purpose: The aim of this study was to use photovoice research methods to capture and explain representative photographs of patients’ experiences with chronic pain.

Closing the Health Disparity Gap: Impact of Health Empowerment Technologies on Elderly African Americans' Health Provider Relationships
PI: Leon McDougle, MD 
Co-I: Randy Wexler, MD 
Purpose: The purpose of this project is to investigate the use of web-based health technologies to improve the patient-doctor relationship of elderly African Americans.

Developing a Communication Tool for Appalachian Breast Cancer Survivors 
PI: Doug Post, PhD 
Purpose: The aim of this study is to design and assess the feasibility of a culturally-relevant, PDA-based communication tool for Appalachian breast cancer survivors undergoing chemotherapy treatment.

Development and Validation of a Measure to Assess Satisfaction with the Patient Centered Medical Home

PI: Randy Wexler, MD 
Purpose: The aim of this study is to measure patient perspectives of Patient-Centered Medical Home (PCMH) implementation and activity through the development of a validated patient survey.

Enhancing Colorectal Cancer Screening in Primary Care
 
PI: Electra Paskett, PhD 
Co-I's: Mary Jo Welker, MD and Doug Post, PhD 
Purpose: The goal of this study is to test a program to improve CRC screening among male and female patients over the age of 50 from the Primary Care Network of The Ohio State University that includes African Americans and older populations.

Longitudinal Intervention: Networking Kare and Educating For Diabetes (LINKED) 
Co-PI: Mary Jo Welker, MD 
Purpose: The aim of this study is to link diabetes patients treated at free clinics to primary care homes and to assess the influence of the linkage to primary care homes on diabetes management and primary care, emergency care and free clinic usage.

Use of HIT to Increase Primary Care Access in Medicaid Patients 
PI: Randy Wexler, MD 
Purpose: The purpose of this study is to use health information technology (HIT) to develop, implement and evaluate an Emergency Department Primary Care Provider Connector Program that aims to: 1) improve access to primary care for Medicaid patients and 2) improve coordination of care across transitions in healthcare settings.

Massage Therapy in Eccentric Exercise Induced Muscle Weakness and Inflammation
PI: Tom Best, MD
Purpose: This basic science research is aimed at understanding the mechanisms of action of massage therapies. Through this study, investigators aim to understand the basis of massage therapy effectiveness and to develop innovative strategies to maximize their clinical effectiveness.

OAMiner: Integrative Knowledge Anchored Hypothesis Discovery
PI: Metin Gurcan, PhD
Co-I: Tom Best, MD
Purpose: The goal of this study is to enable the discovery, verification and validation of hypotheses concerning interrelationships between image-based, phenotypic and bio-molecular features in heterogeneous data sets by leveraging multiple conceptual knowledge sources – ultimately supporting "high throughput" knowledge-driven translational science.

Research Resources

Research Resources

Various resources are available to faculty members to plan, conduct and report research in the Department of Family Medicine. These include internal funding mechanisms, links to local, state and national agencies, Central Ohio Practice-Based Research Network and template descriptions that can be easily modified to fit the needs of a particular grant application.

One individual who should be contacted as a means to personalize the use of available research resources is Pamela Beavers, Pamela.Beavers@osumc.edu. She will be able to provide very personalized help to any person interested in conducting research.

COPBRN

The Central Ohio Practice-Based Research Network (COPBRN) consists of 21 primary care sites – eight family medicine sites of The Ohio State University Primary Care Network, including one shared site with general internal medicine; five Ohio State University Division of General Internal Medicine sites and eight PrimaryOne Health, Inc. sites. This collaborative of clinical networks serves to maximize the diversity, breadth and depth of the available primary care study populations in central Ohio and represents the diverse demographics of the region. 

The COPBRN is committed to the performance of high quality practice-based research in order to add to the primary care knowledge base, enhance the delivery of preventive medicine and positively influence the diagnosis and treatment of health problems of patients, families and communities. The COPBRN is a member of the Agency for Health Research & Quality (AHRQ) PBRN registry and is a member of the Collaborative Ohio Inquiry Network (COIN), a designated Center of Excellence for Primary Care Practice-Based Research and Learning Networks (PCPRLN) recognized by AHRQ. The COPBRN is administratively housed in the Department of Family Medicine at The Ohio State University and is led by a steering committee including representatives from each of the member clinical networks.

Practice-Based Research Network Summary

Investigator PBRN Request Form