While systemic antibiotic prophylaxis in orthopaedic surgeries is the standard practice of care, many disagree over the timing and duration. The American Association of Hip and Knee Surgeons (AAHKS) currently recommends postoperative antibiotics to be continued for 24 hours to mitigate the risk of surgical site infections (SSI). The Centers for Medicare and Medicaid Services guideline for perioperative antibiotics eliminates postoperative dosing.

The Ohio State Wexner Medical Center is one of just 11 sites participating in an international, multicenter prospective randomized study to provide level I evidence for or against the single-dose versus 24-hour antibiotic. The study will include 8,000 primary total knee arthroplasty cases.

“We’re excited to be a part of this research to validate the safety and effectiveness of shorter-duration antibiotic treatment,” says Menghai Li, MD, PhD, director of the Division of Adult Reconstructive Surgery. “Infection in orthopaedic surgery is a dreaded complication. Our participation in the Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty study will hopefully contribute to further lowering the SSI complication rate.”

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