Matthew Kalady

Matthew Kalady, MD

  • Colon and Rectal Surgery
  • General Surgery
  • Physician

Professor of Surgery

Accepting new patients

Insurances We Accept

614-366-4272

About Me

I am a colorectal surgeon who specializes in the evaluation and management of patients with cancer of the colon, rectum and anus. I prioritize good surgical technique to assure that patients get the best cancer outcome and preserve quality of life. With the use of minimally invasive surgery approaches, patients spend less time in the hospital, recover faster and with less pain, and return to normal activities more quickly than traditional incisional surgery.

Along with treating cancer, I strive to prevent cancer before it develops. This includes providing timely cancer screenings. I have a specialized interest and expertise in caring for patients and their families who are at increased risk of developing colorectal or other cancers as a result of a particular family history or inherited condition. This includes Lynch syndrome and familial adenomatous polyposis — conditions that without intervention will almost certainly result in colorectal cancer.

In addition to my role as the director of the Division of Colon and Rectal Surgery, I work closely with certified genetic counselors as the medical director of Clinical Cancer Genetics to provide education and recommendations for genetic testing and screening tests. One of my favorite parts of my job is getting to know patients and their families, and being able to help them through what can be a very difficult time.

As a member of the Cancer Biology Program at the OSUCCC – James, I also strive to understand the underlying causes of why some patients and cancers respond better to certain treatments. My basic science research laboratory is supported by the National Cancer Institute and focuses on identifying genetic pathways or proteins that help prevent the development of cancer or enhance the treatment effect of chemotherapy and radiation. We recently identified a protein present in rectal cancers that is correlated with radiation resistance and also provides a potential target to increase patients’ response to radiation. My ultimate goal is to provide meaningful research that changes the way we care for cancer patients.

I have published more than 200 peer-reviewed manuscripts in such high-impact journals as New England Journal of Medicine, Science, Nature Communications, JAMA Oncology, Gastroenterology, Journal of Clinical Oncology and Annals of Surgery. I am also a member of several prominent professional organizations, including the American Surgical Association, the Society of Clinical Surgery, the Society of Surgical Oncology, and the American Society of Colon and Rectal Surgeons. Additionally, I have consistently been named to the Castle Connolly and U.S. News and World Report lists of “Top Doctors” since 2011.

I love the collaborative approach to patient care at The James, from the multidisciplinary team discussion that leads to a care plan, to the tumor genetics evaluation that might drive personalized treatment trials or research, to the support services that care for the whole patient — physical, spiritual and emotional. Everyone prioritizes the patient and works together to make sure they receive top-notch care.
Highlights
  • Named to Castle Connolly's Regional Top Doctors list

Procedures and Conditions I Treat

  • Crohn Disease
  • Colorectal Surgery
  • Inflammatory Bowel Diseases
  • Colorectal Diseases
  • Robotics
  • Colorectal Cancers
  • Colon Cancers
  • Ulcerative Colitis
  • Rectal Cancers
  • Anal Cancers
  • Lynch Syndrome II

Locations Where I Practice

Please note: Not all physicians schedule patients at each listed location.

Education and Training

Education History

Medical School

Duke University School of Medicine, Durham, NC
8/1/1994 - 5/31/1998

Residency

Duke University Medical Center, Durham, NC
6/1/1998 - 6/30/2000

Fellowship

Duke University Medical Center, Durham, NC
7/1/2000 - 6/30/2002

Residency

Duke University Medical Center, Durham, NC
7/1/2002 - 6/30/2005

Fellowship

Cleveland Clinic Foundation, Cleveland, OH
7/1/2005 - 6/30/2006

Board Certifications

American Board of Surgery
3/21/2006

American Board of Colon & Rectal Surgery
9/29/2007

Academic Information

My Department

Surgery

My Division

Colon and Rectal Surgery

More About My Work

Reviews

The overall patient satisfaction rating is an average of all patient responses to the six doctor communication related questions shown below from the Clinician and Group Consumer Assessment of Healthcare Providers and Systems survey. For additional information about the patient satisfaction survey, please visit our Patient Satisfaction Survey page.

The comments are submitted by patients and reflect their view and opinions. The comments are not endorsed by and do not necessarily reflect the views of Ohio State Wexner Medical Center.

194 Patient Satisfaction Reviews

  • Overall
    4.9 out of 5
  • Kept you informed about your condition and treatment
    4.8 out of 5
  • Amount of time spent with you
    4.8 out of 5
  • Concern for your questions and issues
    4.8 out of 5
  • Skill and knowledge
    4.8 out of 5
  • Overall quality of care
    4.9 out of 5
  • Reviewed on Nov 15, 2025

    Very informative and professional

  • Reviewed on Nov 07, 2025

    Dr. Kalady and Stephanie have been excellent and through in their appointments and follow-up, especially as we didn't have all the information/testing results that were needed at the time of my initial appointment. I am especially grateful to Stephanie Mitchem for her compassion during my appointment/procedure and extensive follow-up after we had our final results and tumor board had met.

  • Reviewed on Oct 31, 2025

    I've been well-informed at every phase of my treatment and follow ups

  • Reviewed on Oct 26, 2025

    Good

  • Reviewed on Oct 25, 2025

    VERY PLEASED

  • Reviewed on Oct 10, 2025

    They are fantastic

  • Reviewed on Sep 12, 2025

    Good

  • Reviewed on Sep 02, 2025

    Really don't have any complaints the entire time I have been receiving care thank you

Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.

As of 09/30/2024, Dr. Kalady has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.

  • Activ Surgical

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