2017 Schottenstein Prize Laureate
The 2017 Jay and Jeanie Schottenstein Prize in Cardiovascular Sciences has been awarded to Dr. Helen H. Hobbs of UT Southwestern Medical Center. Dr. Hobbs received her medical degree from Case Western Reserve University (Cleveland, OH) before completing an internship in internal medicine at Columbia-Presbyterian Medical Center (NYC, NY). She moved to Dallas, TX to finish her clinical training and being chief resident in internal medicine. After completing a post-doctoral fellowship in the laboratory of Drs. Joseph Goldstein and Michael Brown, she joined the UT Southwestern faculty.
Dr. Hobbs is currently a Professor of Internal Medicine and Molecular Genetics and since 2002 has been a Howard Hughes Investigator. In 1999, Dr. Hobbs started the Dallas Heart Study (DHS), a phenotypically well-characterized, multiethnic, population-based study in Dallas. Together with Jonathan Cohen, she performed studies in this cohort to show that rare and low frequency variants contribute to complex traits in the general population and can provide powerful tools to identify therapeutic targets. Dr. Hobbs showed that low frequency variants in PCSK9 not only lower plasma levels of LDL-cholesterol, but also protection from heart disease. Recently, two anti-PCSK9 antibodies were approved by the FDA for treatment of individuals with hypercholesterolemia.
Dr. Hobbs was elected to the Institute of Medicine in 2004 and the National Academy of Sciences in 2007. She was awarded the Breakthrough Prize in Life Sciences in 2015 and the Passano Award (with Jonathan Cohen) in 2016.