When you participate in a research study, you become a vital part of a team working to change the future of health care and improve lives.

Research study volunteers are essential in shaping the future of medicine. Whether it's a clinical trial of an experimental medication, a comparison of different treatments or a collection of data from people with a similar health condition or genetic background, community participants help researchers translate scientific discovery into lifesaving care. Many of our research studies are specific to knee, shoulder or hip medical procedures or conditions for which you may be a candidate.

If you have an interest in or question regarding our research projects, please browse our current studies below, contact ask your provider if you qualify or contact us at SportsMedResearch@osumc.edu.


ACL Tear

Assessing ACL graft viability

The use of allograft tissue in anterior cruciate ligament (ACL) reconstruction has been associated with increased failure rates, the cause of which is unclear and likely multifactorial; it is believed that different patterns of revascularization and ligamentization may contribute. Positron emission tomography (PET) scans have the capacity to demonstrate revascularization as well as metabolic activity of tissues. Chemical exchange saturation transfer (proteinCEST) imaging can also assess the intra-articular environment. This study is being done to explore this new method of imaging.

Evaluating ACL reconstruction success factors

This multi-year study gathers data on the knee before, during and after ACL reconstruction in order to determine what factors may help or hinder the success of an ACL reconstruction. If you have been diagnosed with an ACL tear and are planning on having an ACL reconstruction, you may be eligible to participate.

Identifying athletes at risk for ACL injury

Athletes who participate in pivoting, cutting, and jumping sports have a greater chance of suffering an ACL injury compared to most other athletes. The purpose of this study is to develop new, low-cost strategies for identifying athletes at risk of anterior cruciate ligament (ACL) injury. Healthy participants will undergo 3D motion analysis using skin-mounted muscle activity monitoring known as electromyography (EMG) and magnetic resonance imaging (MRI) of the knee and leg. By creating a computer model of participant's knees, we will be able to more accurately describe the effect of the way the participant moves during athletic tasks on their risk of injury. 

The Modeling Study: ACL Injury Risk in Active Individuals 14-35 

Knee Cartilage

Outcomes of cartilage injuries

Injury to the cartilage in the knee, called focal chondral defects, may impact function, muscle strength and the way you move. The outcomes of individuals with focal chondral defects are unknown. Findings from this study will provide information regarding the function, muscle strength, movement and muscle activation patterns, and potential for progressive damage on the cartilage of individuals with focal chondral defects in the knee.

Tissue engineered cell-based repair product

Novocart® 3D is a cellular implant system where small amount of knee cartilage is removed in a an initial surgery, cleaned and "grown" on a 3-dimensional sponge-like scaffold and then implanted into the damaged area in a second surgery approximately 3 weeks later. This Phase 3 prospective, randomized, partially blinded multi-center study measures the safety and efficacy of Novocart compared to the current Microfracture standard of care in repairing articular cartilage defects of the knee.

Novocart®3D for Treatment of Articular Cartilage of the Knee

Implant for joint surface lesions

This study compares the efficacy and safety of the Agili-C implant to the surgical standard of care treatment in patients suffering from joint surface lesions of the knee. Agili-C™ is a cell-free, off-the-shelf implant for use in cartilage and osteochondral defects in traumatic and osteoarthritic joints. The implant is a porous, biocompatible, and resorbable bi-phasic scaffold, consisting of interconnected natural inorganic calcium carbonate.

A Treatment Study of Joint Surface Lesions of the Knee - Agili-C™ vs. Surgical Standard of Care

Regeneration of hyaline-like cartilage

This is a prospective, randomized trial designed to compare two treatments for articular cartilage defect legions: microfracture and Hyalofast® scaffold. Hyalofast is made from a synthetic form of a substance called hyaluronic acid that is found naturally in the knee joint and other places throughout the body. It is combined with autologous bone marrow aspirate concentrate and surgically implanted into the cartilage defect. It is believed that the bone marrow cells eventually will grow into new cartilage and fill the defect while the Hyalofast® eventually dissolves away with time.

A Treatment Study for Damaged Knee Cartilage Requiring Repair--Hyalofast with BMAC

Knee General

Dry Needling for "Runner's Knee"

This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.

The Effects of Dry Needling on Knee Pain

Subchondroplastyâ„¢ for Bone Marrow Lesions

This observational cohort follow-up study seeks to understand the post-operative outcomes of subjects choosing to undergo the Subchondroplasty™ (SCP™) procedure, a minimally invasive procedure to treat bone defects in the knee associated with bone marrow lesions (BMLs). BMLs are subchondral defects in the bone, also called insufficiency fractures. This follow-up study will collect information on the short- and long-term safety and effectiveness of the SCP procedure.

Follow-up Study for Those Who Have Undergone (or Will Undergo) the Subchondroplasty (SCP) Knee Procedure

Moximed Calypso

The Calypso Knee System is an investigational device designed to treat knee OA by absorbing excess load placed on your joint. OA usually affects the “inner side” of the knee, and the Calypso Knee System has been designed specifically to address this type of pain. Once implanted, the Calypso Knee System works like a shock absorber for your knee, designed to restore a more normal load balance within the joint. 

The Calypso Knee System is implanted under the skin, alongside your knee joint, through a single incision. And unlike joint replacement procedures, none of your bone, ligament, or cartilage is removed, which may help maintain future treatment options.


Joint Health Assessment Study

Degenerative disease of the knee joint is an increasingly common condition. Cases of advanced joint degeneration lead to significant disability and often require invasive, expensive treatments. This study evaluates normal and injured knees of patients in different age groups and sexes to determine the value of certain pictures taken by a Magnetic Resonance Image (MRI) machine.

First Time Patellar Dislocation

Patellar dislocations are debilitating injuries that frequently affect young, active patients. In spite of the relatively high incidence of this condition, significant controversy remains regarding the ideal treatment protocol. This study evaluates patients following their treatment for patellar dislocation to help in future treatments for those with the same condition.

Knee Joint Bracing and Neuromuscular Training

The purpose of this study is to evaluate the ability of neuromuscular training and knee braces to reduce the risk of suffering a knee injury. Neuromuscular training typically involves controlled movement tasks such as side-stepping, jumping, and plyometrics under the supervision of a trained clinical specialist. Knee braces may also have the potential to help ‘train’ the knee by providing feedback to an athlete when their knee is moving in a way that could cause it to get injured.


Outcomes of surgical treatments for shoulder instability

The purpose of this research study is to obtain long-term follow-up information on people with shoulder instability. The data from all Ohio State patients undergoing operative treatment will be combined with the data from all other sites and housed at the coordinating site (University of Iowa). This database will be statistically analyzed to learn about how people do after surgical treatment for shoulder instability including return to activities, pain and additional treatment or surgery.

Shoulder Instability Surgery Outcome Study


This is an unblinded, multi-center, pragmatic randomized controlled clinical trial of operative versus non-operative treatments for atraumatic rotator cuff tears. A sample size of 700 patients will be enrolled with approximately equal numbers of patients randomized to operative treatment (surgery + post-op physical therapy) and non-operative treatment (physical therapy only without surgery). Both treatments are current standards of care.


Learn more

Outcomes of shoulder surgery

Data will be collected for all patients undergoing shoulder operative treatment at Ohio State regarding their return to activity, level of pain and additional treatments during regularly scheduled post-ops visits to better understand outcomes. 


Hip Treatment Outcomes

This research project follows individuals receiving treatments for common and painful hip conditions over the course of several years to determine which factors predict both short- and long-term functional outcomes. This information will be used to optimize the care of patients who are treated surgically as well as non-surgical interventions such as medications, injections and physical therapy.

Database for Hip Treatment Patients

Interdisciplinary Approach for Hip Pain

The purpose of this study is to better understand whether or not interdisciplinary care can impact treatment decisions and outcomes for patients with non-arthritic hip pain. Patients who participate will be placed in 1 of 2 groups: they will either receive 1) their standard evaluation with a hip surgeon or 2) their standard evaluation with a hip surgeon followed by a brief assessment with a physical therapist. Both groups will have the opportunity to continue onto a treatment trial in which they may receive 3 weeks of physical therapy focused on posture and movement.

Interdisciplinary Approach for Hip Pain

Subchondroplastyâ„¢ for bone marrow lesions in the hip

The Subchondroplasty® (SCP®) Procedure is a minimally-invasive surgery that targets and fills subchondral bone defects, often referred to as Bone Marrow Lesions (BML).  The procedure is usually performed along with arthroscopy (""scoping"") of the nearby joint, allowing the surgeon to visualize and treat findings inside the joint. This study is collecting data on the short- and long-term outcomes for those who have had the SCP hip procedure, including medication usage, pain, function, activity levels and patient satisfaction.

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Treatment for Greater Trochanteric Pain Syndrome (Lateral Hip Pain)

The purpose of this study is to compare the effects of two different physical therapy programs on pain and function in individuals diagnosed with greater trochanteric pain syndrome (GTPS) (also known as lateral hip pain). Patients who participate will receive instruction from a physical therapist regarding 1 of 2 exercise programs to complete over a 4-week period at home.

Treatment for Greater Trochanteric Pain Syndrome

Other Trials

Use of Screenings and Injury Tracking to Promote Wellness in Dancers

This study will investigate trends and correlations between dancer screening test results, medical history and injury occurrence to impact future clinical practice.

Preoperative Psychometric Screening

Differences in psychological and behavioral responses to pain are some of the most well studied factors that may contribute to a lack of return to sport. The purpose of this study is to determine whether pre-operative psychological screening can determine future risk of an unsatisfactory outcome after sports-related knee surgery, providing risk estimation data that may allow surgeons to more appropriately recommend operative vs. conservative treatment.

The Walking Study: Mediators of Exercise Driven Musculoskeletal Health

Physical inactivity is a major cause for the onset and progression of bone and muscle disorders/diseases, suggesting that the human body regulates bone and muscle health together as one. Research has shown that exercise can help to prevent bone loss and strengthen bones and muscles, yet exercise is not extensively used as a therapy. In this study, we are hoping to uncover how exercise regulates bone and muscle health. Using this information, we might then be able to measure how exercise is increasing health or how to best use exercise in specific ways as therapy to increase health.

The Walking Study: Mediators of Exercise Driven Musculoskeletal Health

Imaging Quality and Anatomical Variability in Standard of Care

Imaging pictures from patients undergoing Magnetic Resonance Imaging (MRI) of the joint will have the option of extra Chemical Exchange Saturation Transfer (CEST) imaging sequences. The data will be reviewed for the purposes of image quality and assessing feasibility of musculoskeletal imaging.

Media highlights of some of our recent basic science studies and clinical trials

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