The use of allograft tissue in anterior cruciate ligament (ACL) reconstruction has been associated with increased failure rates, the cause of which is unclear and likely multifactorial; it is believed that different patterns of revascularization and ligamentization may contribute. Positron emission tomography (PET) scans have the capacity to demonstrate revascularization as well as metabolic activity of tissues. Chemical exchange saturation transfer (proteinCEST) imaging can also assess the intra-articular environment. This study is being done to explore this new method of imaging.

In the BEAR^® procedure (bridge-enhanced ACL restoration), the torn ACL fibers are instead sutured and stitched into the center of the knee with an implant that absorbs your own blood. This provides a healing environment for the torn ACL fibers to repair themselves together.

The BEAR-MOON trial aims to compare the BEAR^® technique against standard anterior cruciate ligament (ACL) reconstruction with a graft.

The BEAR-MOON trial addresses the question of whether this new and less invasive surgical procedure can provide non-inferior outcomes to the gold standard of treatment in terms of knee laxity and patient-reported outcomes.

This multi-year study gathers data on the knee before, during and after ACL reconstruction in order to determine what factors may help or hinder the success of an ACL reconstruction. If you have been diagnosed with an ACL tear and are planning on having an ACL reconstruction, you may be eligible to participate.

Athletes who participate in pivoting, cutting, and jumping sports have a greater chance of suffering an ACL injury compared to most other athletes. The purpose of this study is to develop new, low-cost strategies for identifying athletes at risk of anterior cruciate ligament (ACL) injury. Healthy participants will undergo 3D motion analysis using skin-mounted muscle activity monitoring known as electromyography (EMG) and magnetic resonance imaging (MRI) of the knee and leg. By creating a computer model of participant's knees, we will be able to more accurately describe the effect of the way the participant moves during athletic tasks on their risk of injury. 

The Modeling Study: ACL Injury Risk in Active Individuals 14-35 

Injury to the cartilage in the knee, called focal chondral defects, may impact function, muscle strength and the way you move. The outcomes of individuals with focal chondral defects are unknown. Findings from this study will provide information regarding the function, muscle strength, movement and muscle activation patterns, and potential for progressive damage on the cartilage of individuals with focal chondral defects in the knee.

Novocart® 3D is a cellular implant system where small amount of knee cartilage is removed in a an initial surgery, cleaned and "grown" on a 3-dimensional sponge-like scaffold and then implanted into the damaged area in a second surgery approximately 3 weeks later. This Phase 3 prospective, randomized, partially blinded multi-center study measures the safety and efficacy of Novocart compared to the current Microfracture standard of care in repairing articular cartilage defects of the knee.

Novocart®3D for Treatment of Articular Cartilage of the Knee

The main purpose of this study is to test the safety and effectiveness of CartiLife® for cartilage lesions in the knee. CartiLife is an implant composed of extracellular matrix-associated autologous chondrocytes composed as pellets.

This research study explores the potential medical benefits and safety of an investigational implant that is intended to be used as a cartilage and bone replacement for your knee joint compared to microfracture. This investigational device is known as the Episealer® knee implant, made of metal alloy, which is custom made for your knee by 3D modeling. 

This is a prospective, randomized trial designed to compare two treatments for articular cartilage defect legions: microfracture and Hyalofast® scaffold. Hyalofast is made from a synthetic form of a substance called hyaluronic acid that is found naturally in the knee joint and other places throughout the body. It is combined with autologous bone marrow aspirate concentrate and surgically implanted into the cartilage defect. It is believed that the bone marrow cells eventually will grow into new cartilage and fill the defect while the Hyalofast® eventually dissolves away with time.

A Treatment Study for Damaged Knee Cartilage Requiring Repair--Hyalofast with BMAC

The purpose of this GID Bio, Inc. study is to determine whether treatment of stromal vascular fraction cells for osteoarthritis of the knee relieves pain and increases function. Patients will be randomly selected to be in 1 of the 2 groups (stem cells or placebo) and both patient and doctor will not know which group subjects are in until the study is over. Patients will have a 75% chance of receiving stromal vascular fraction treatment and 25% chance of receiving the placebo treatment.

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The purpose of this study is to compare 3 different knee injection medications that are commonly used in clinical practice to treat knee osteoarthritis to see if one is better than the others. This study is being done to help physicians gather information that they can share with future patients on commonly used knee injections used to treat knee osteoarthritis. By doing this study, we hope to better understand if one injection is better than the others.

This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.

The Effects of Dry Needling on Knee Pain

The study is a prospective, multicenter clinical study evaluating clinical and patient reported outcome measures of subjects receiving IntraOsseous BioPlasty (IOBP) surgical technique. This uses concentrated platelet rich plasma from your bone marrow to treat subchondral bone pathologies in the knee. The procedure is designed to decrease pressure in the knee by restoring blood flow to the bone. 

Degenerative disease of the knee joint is an increasingly common condition. Cases of advanced joint degeneration lead to significant disability and often require invasive, expensive treatments. This study evaluates normal and injured knees of patients in different age groups and sexes to determine the value of certain pictures taken by a Magnetic Resonance Image (MRI) machine.

Patellar dislocations are debilitating injuries that frequently affect young, active patients. In spite of the relatively high incidence of this condition, significant controversy remains regarding the ideal treatment protocol. This study evaluates patients following their treatment for patellar dislocation to help in future treatments for those with the same condition.

The purpose of this study is to evaluate the ability of neuromuscular training and knee braces to reduce the risk of suffering a knee injury. Neuromuscular training typically involves controlled movement tasks such as side-stepping, jumping, and plyometrics under the supervision of a trained clinical specialist. Knee braces may also have the potential to help ‘train’ the knee by providing feedback to an athlete when their knee is moving in a way that could cause it to get injured.