Driving High-Impact Innovation

BEAR – MOON: A Two Arm Non-Inferiority Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

We are testing a new surgery called the BEAR (Bridge-Enhanced ACL Restoration) which uses the BEAR implant (bridging sponge) instead replacing your ACL. We randomize patients in order to compare the BEAR technique against the standard ACL reconstruction with a graft.

Inclusion Criteria: 18-55yo, recent first ACL tear with no previous knee surgery on either knee.

Principal Investigator: Dr. Christopher Kaeding
Research Coordinator: Tabi Pontious

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Indicators of Bacterial Colonization in Failed ACL Reconstructions: A Pilot Study

This study is to find out why some ACL reconstructions fail. Specifically, we want to know if some people with failed ACL reconstructions have small amounts of bacteria present in their torn graft that may have caused it to weaken over time.

Inclusion Criteria: ACL reconstruction failure

Principal Investigator: Dr. David Flanigan
Research Coordinator: Tabi Pontious

This multi-year study gathers data on the knee before, during and after ACL reconstruction in order to determine what factors may help or hinder the success of an ACL reconstruction. If you have been diagnosed with an ACL tear and are planning on having an ACL reconstruction, you may be eligible to participate.

Physical Activity and Symptoms in Individuals with Femoroacetabular Impingement Syndrome and ACLR

The purpose of this study is to evaluate how physical activity and loading during real-world activities are related to symptoms in those with ACL reconstruction.

Inclusion Criteria: 18-40 years old, ACL reconstruction. Participants must have access to a smartphone.

Principal Investigator: Stephanie Di Stasi

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Preventing Injured Knees from osteoArthritis: Severity Outcomes (PIKASO)

A study to establish the efficacy of metformin at delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction.

Inclusion Criteria: 18-45yo, with first ACL tear with no previous ACL surgery in either knee.

Principal Investigator: Dr. Laura Schmitt
Research Coordinator: Tabi Pontious

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A Prospective, Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Episealer® Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions

This research study explores the potential medical benefits and safety of an investigational implant that is intended to be used as cartilage and bone replacement for your knee joint compared to microfracture. This investigational device is known as the Episealer® knee implant, made of metal alloy, which is custom made for your knee by 3D modeling.

Inclusion Criteria: 30-70 years old with knee pain and MRI confirmation of cartilage defect in the knee.

Principal Investigator: Dr. David Flanigan
Research Coordinator: Jenna DeFranco

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This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.

The Effects of Dry Needling on Knee Pain

JUPITER 3 and 4: Justifying Patellar Instability Treatment by Early Results

The purpose of this research study is to obtain long-term follow-up information in order to learn about how people do over time after undergoing surgical or non-surgical treatment for patellar instability, including return to activities, pain, and additional treatment or surgery.

Inclusion Criteria: 10-35 years old and first time or multiple patellar instability episodes

Principal Investigator: Dr. Robert Magnussen
Research Coordinator: Michael Keller

The purpose of this study is to compare 3 different knee injection medications that are commonly used in clinical practice to treat knee osteoarthritis to see if one is better than the others. This study is being done to help physicians gather information that they can share with future patients on commonly used knee injections used to treat knee osteoarthritis. By doing this study, we hope to better understand if one injection is better than the others.

Post-Market Evaluation of the MISHA™ Knee System for Symptom Relief in Subjects with Medial Knee Osteoarthritis

The purpose of this study is to evaluate the post-market procedural and long-term results of the MISHA Knee System. The MISHA Knee System is an implantable shock absorber (ISA) designed to relieve knee pain in patients with osteoarthritis (OA). The ISA works like a car shock absorber – it reduces the amount of force on your painful knee joint.

Inclusion Criteria: 25-65 years old, knee pain, and failure of other knee OA treatments

Principal Investigator: Dr. David Flanigan
Research Coordinator: Jenna DeFranco

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A Phase 3 Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study To Evaluate The Efficacy Of Amniotic Suspension Allograft (Asa) In Patients With Osteoarthritis Of The Knee

The purpose of this study is to learn more about the safety of amnion suspension allograft (ASA) by injection, and its potential for treating symptoms of OA of the knee. ASA is a human tissue allograft. It is made from cells from amniotic fluid and amniotic membrane. Amniotic tissue is thought to promote healing by reducing inflammation.

Inclusion Criteria: At least 18yo, knee pain, and failure of other knee OA treatments

Principal Investigator: Dr. David Flanigan
Research Coordinator: Jenna DeFranco

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A Phase 2, 52-Week Trial of TTAX03 vs. Saline as a Single Intra-articular Injection in Kellgren- Lawrence Grade 3-4 Knee OA

The purpose of this study is to examine the safety, effectiveness and duration of an injection of TTAX03. TTAXX03 is an umbilical cord and amniotic membrane product that is donated and processed into an injectable solution that is being investigated for the approval of knee OA.

Inclusion Criteria: 35-85yo, knee pain, and failure of other knee OA treatments

Principal Investigator: Dr. David Flanigan
Research Coordinator: Jenna DeFranco

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The purpose of this study is to collect clinical and microbiological outcomes on patients undergoing Total Shoulder Arthroplasty Revision (TSA-Revision). This data will then be entered into a database with information from other sites around the country. Data from this study will help go on to optimize prevention and management of periprostheitc joint infections (PJI).

Multicenter Prospective Study of Zimmer Biomet mymobility Application of Reverse Total Shoulder Arthroplasty (RTSA) Outcomes

The purpose of this study is to compare the postoperative outcomes following a Reverse Total Shoulder Arthroplasty (RTSA) between two different physical therapy rehabilitation groups as each group completes standard of care (SOC) rehabilitation exercises.

Inclusion Criteria: 18 and older that are scheduled for primary reverse total shoulder that plan to complete PT at a facility.

Principal Investigator: Dr. Ryan Rauck
Research Coordinator: Kate Agan

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Shoulder ID™ Primary Reversed Glenoid Outcomes Clinical Study

The purpose of this study is to collect information on the safety and performance of the Shoulder iD device. The study will measure patient-reported outcomes related to quality of life, function and pain following surgery.

Inclusion Criteria: 18 and older, considered a candidate for the reverse shoulder using the Shoulder ID device

Principal Investigator: Dr. Greg Cvetanovich
Research Coordinator: Kate Agan

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Open versus Arthroscopic Stabilization for Shoulder Instability with Subcritical Bone Loss

The purpose of this study is to determine the optimal shoulder surgery and rehabilitation strategy for patients. To determine which treatment has the best outcomes, we will follow participants who undergo different stabilization procedures and compare their outcomes.

Inclusion Criteria: 17-50yo with a traumatic anterior shoulder dislocation and associated 10-20% glenoid bone loss and undergoing 1 of the 3 surgeries of interest

Principal Investigator: Dr. Julie Bishop
Research Coordinator: Kate Agan

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The purpose of this research study is to obtain long-term follow-up information on people with shoulder instability. The data from all Ohio State patients undergoing operative treatment will be combined with the data from all other sites and housed at the coordinating site (University of Iowa). This database will be statistically analyzed to learn about how people do after surgical treatment for shoulder instability including return to activities, pain and additional treatment or surgery.

Shoulder Instability Surgery Outcome Study

Data will be collected for all patients undergoing shoulder operative treatment at Ohio State regarding their return to activity, level of pain and additional treatments during regularly scheduled post-ops visits to better understand outcomes. 

This study evaluates how patients heal after surgical treatment of their gluteal tendon injury. This is a one-year study following people undergoing gluteal tendon repair. The study will test how well your tendon is healing through ultrasound evaluations, range of motion measurements, strength measurements, and questionnaires that you will complete both before and after surgery.

Physical Activity and Symptoms in Individuals with Femoroacetabular Impingement Syndrome and ACLR

The purpose of this study is to evaluate how physical activity and loading during real-world activities are related to symptoms in those with FAIS

Inclusion Criteria: 18-40 yo, diagnosis of FAIS. Participants must have access to a smartphone.

Principal Investigator: Stephanie Di Stasi

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The Subchondroplasty® (SCP®) Procedure is a minimally-invasive surgery that targets and fills subchondral bone defects, often referred to as Bone Marrow Lesions (BML).  The procedure is usually performed along with arthroscopy (""scoping"") of the nearby joint, allowing the surgeon to visualize and treat findings inside the joint. This study is collecting data on the short- and long-term outcomes for those who have had the SCP hip procedure, including medication usage, pain, function, activity levels and patient satisfaction.

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This study will investigate trends and correlations between dancer screening test results, medical history and injury occurrence to impact future clinical practice.

Differences in psychological and behavioral responses to pain are some of the most well studied factors that may contribute to a lack of return to sport. The purpose of this study is to determine whether pre-operative psychological screening can determine future risk of an unsatisfactory outcome after sports-related knee surgery, providing risk estimation data that may allow surgeons to more appropriately recommend operative vs. conservative treatment.

Physical inactivity is a major cause for the onset and progression of bone and muscle disorders/diseases, suggesting that the human body regulates bone and muscle health together as one. Research has shown that exercise can help to prevent bone loss and strengthen bones and muscles, yet exercise is not extensively used as a therapy. In this study, we are hoping to uncover how exercise regulates bone and muscle health. Using this information, we might then be able to measure how exercise is increasing health or how to best use exercise in specific ways as therapy to increase health.

The Walking Study: Mediators of Exercise Driven Musculoskeletal Health

Imaging pictures from patients undergoing Magnetic Resonance Imaging (MRI) of the joint will have the option of extra Chemical Exchange Saturation Transfer (CEST) imaging sequences. The data will be reviewed for the purposes of image quality and assessing feasibility of musculoskeletal imaging.