Research drives high-impact innovation
Research study volunteers are essential in shaping the future of medicine. Whether it's a clinical trial of an experimental medication, a comparison of different treatments or a collection of data from people with a similar health condition or genetic background, community participants help researchers translate scientific discoveries into lifesaving care. Many of our research studies are specific to knee, shoulder or hip medical procedures or conditions.
Do you qualify for a Sports Medicine clinical trial?
If you have an interest in, or a question regarding our Sports Medicine research projects, please browse our current studies below, or ask your provider if you qualify. For more information, you can call 614-293-2761 or email SportsMedResearch@osumc.edu to see if you are eligible to participate in one of our current clinical trials.
ACL Tear
BEAR – MOON: A Two Arm Non-Inferiority Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction
We are testing a new surgery called the BEAR (Bridge-Enhanced ACL Restoration) which uses the BEAR implant (bridging sponge) instead replacing your ACL. We randomize patients in order to compare the BEAR technique against the standard ACL reconstruction with a graft.
Inclusion Criteria: 18-55yo, recent first ACL tear with no previous knee surgery on either knee.
Principal Investigator: Christopher Kaeding, MD
Research Coordinator: Tabi Pontious
This multi-year study gathers data on the knee before, during and after ACL reconstruction in order to determine what factors may help or hinder the success of an ACL reconstruction. If you have been diagnosed with an ACL tear and are planning on having an ACL reconstruction, you may be eligible to participate.
Physical Activity and Symptoms in Individuals with Femoroacetabular Impingement Syndrome and ACLR
The purpose of this study is to evaluate how physical activity and loading during real-world activities are related to symptoms in those with ACL reconstruction.
Inclusion Criteria: 18-40 y.o., who have had their first ACL reconstruction. Participants must have access to a smartphone in order to complete daily surveys.
Principal Investigator: Stephanie Di Stasi, PhD, PT
Research Coordinator: Stephanie.DiStasi@osumc.edu
Preventing Injured Knees from osteoArthritis: Severity Outcomes (PIKASO)
A study to establish the efficacy of metformin at delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction.
Inclusion Criteria: 18-45 y.o., with first ACL tear with no previous ACL surgery in either knee.
Principal Investigator: Laura Schmitt, PhD, PT
Research Coordinator: Tabi Pontious
Knee Cartilage
Evalution of the Patellar Lift System for Subjects with Patellofemoral Cartilage Degeneration (PELICAN)
This study compares clinical outcomes, safety and effectiveness of the LIFT System when used in subjects with symptomatic patellofemoral cartilage degeneration including osteoarthritis. The ZKR LIFT implant uses the principle of unloading to reduce patellofemoral forces in hopes to reduce pain and increase function.
Inclusion Criteria: 22-65 y.o. with patellofemoral cartilage degeneration after failing at least 6 months of non-surgical treatment.
Principal Investigator: David Flanigan, MD
Research Coordinator: Jenna DeFranco
A Prospective, Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Effectiveness of the Episealer® Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions
This research study explores the potential medical benefits and safety of an investigational implant that is intended to be used as cartilage and bone replacement for your knee joint compared to microfracture. This investigational device is known as the Episealer® knee implant, made of metal alloy, which is custom made for your knee by 3D modeling.
Inclusion Criteria: 30-70 y.o. with knee pain and MRI confirmation of cartilage defect in the knee.
Principal Investigator: David Flanigan, MD
Research Coordinator: Jenna DeFranco
Knee General
This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.
Principal Investigator: Matt Briggs, PT, PhD
Research Coordinator: Matt.Briggs@osumc.edu
JUPITER 3 and 4: Justifying Patellar Instability Treatment by Early Results
The purpose of this research study is to obtain long-term follow-up information in order to learn about how people do over time after undergoing surgical or non-surgical treatment for patellar instability, including return to activities, pain, and additional treatment or surgery.
Inclusion Criteria: 10-35 y.o. and first-time or multiple patellar instability episodes.
Principal Investigator: Robert Magnussen, MD
Research Coordinator: Michael Keller
Knee Osteoarthritis
A Phase 1b Open-Label, Multicenter, Randomized Trial to Evaluate the Safety of PEP and EUFLEXXA for the Treatment of Participants with Knee Osteoarthritis (KOA)
This is a randomized study to evaluate the safety and efficacy of a single injection of Purified Exosome Product (PEP) with and without EUFLEXXA in the knee of adult patients with symptomatic unilateral knee osteoarthritis.
Inclusion Criteria: 18-90 y.o., with unilateral knee pain for at least 6 months and failure of other knee OA treatments.
Principal Investigator: Michael Baria, MD
Research Coordinator: Sarah Jia
Evaluation of the MISHA® Knee System for Symptom Relief in Subjects with Medial Knee Osteoarthritis versus the use of non-surgical treatment: Randomized Assessment and Comparison of Therapies for Medial Knee Osteoarthritis
The purpose of this study is to evaluate the post-market procedural and long-term results of the MISHA Knee System. The MISHA Knee System is an implantable shock absorber (ISA) designed to relieve knee pain in patients with osteoarthritis (OA). The ISA works like a car shock absorber – it reduces the amount of force on your painful knee joint.
Inclusion Criteria: Medial knee pain, and failure of other knee OA treatments
Principal Investigator: Robert Magnussen, MD
Research Coordinator: Jenna DeFranco
Shoulder
A Phase 3, Multicenter, Randomized, Double-blind, Single-dose Study to Evaluate the Efficacy and Safety of ZILRETTA in Subjects with Glenohumeral Osteoarthritis
The primary objective of this study is to assess the efficacy of ZILRETTA on pain following a shoulder injection in subjects with glenohumeral OA relative to normal saline placebo.
Inclusion Criteria: 50-80 y.o., with shoulder pain associated with osteoarthritis for more than 3 months
Principal Investigator: Ryan Rauck, MD
Research Coordinator: Sarah Jia
The purpose of this study is to collect clinical and microbiological outcomes on patients undergoing Total Shoulder Arthroplasty Revision (TSA-Revision). This data will then be entered into a database with information from other sites around the country. Data from this study will help go on to optimize prevention and management of periprosthetic joint infections (PJI).
Inclusion Criteria: All patients undergoing a revision shoulder arthroplasty that have not had recent treatment for a presumed shoulder PJI
Principal Investigator: Gregory Cvetanovich, MD
Research Coordinator: Kate Agan
Multicenter Prospective Study of Zimmer Biomet mymobility Application of Reverse Total Shoulder Arthroplasty (RTSA) Outcomes
The purpose of this study is to compare the postoperative outcomes following a Reverse Total Shoulder Arthroplasty (RTSA) between two different physical therapy rehabilitation groups as each group completes standard of care (SOC) rehabilitation exercises.
Inclusion Criteria: 18 and older that are scheduled for primary reverse total shoulder that plan to complete PT at a facility.
Principal Investigator: Ryan Rauck, MD
Research Coordinator: Kate Agan
Shoulder ID™ Primary Reversed Glenoid Outcomes Clinical Study
The purpose of this study is to collect information on the safety and performance of the Shoulder iD device. The study will measure patient-reported outcomes related to quality of life, function and pain following surgery.
Inclusion Criteria: 18 and older, considered a candidate for the reverse shoulder using the Shoulder ID device
Principal Investigator: Gregory Cvetanovich, MD
Research Coordinator: Kate Agan
Open versus Arthroscopic Stabilization for Shoulder Instability with Subcritical Bone Loss
The purpose of this study is to determine the optimal shoulder surgery and rehabilitation strategy for patients. To determine which treatment has the best outcomes, we will follow participants who undergo different stabilization procedures and compare their outcomes.
Inclusion Criteria: 17-50 y.o. with a traumatic anterior shoulder dislocation and associated 10-20% glenoid bone loss and undergoing 1 of the 3 surgeries of interest.
Principal Investigator: Julie Bishop, MD
Research Coordinator: Kate Agan
The purpose of this research study is to obtain long-term follow-up information on people with shoulder instability. The data from all Ohio State patients undergoing operative treatment will be combined with the data from all other sites and housed at the coordinating site (University of Iowa). This database will be statistically analyzed to learn about how people do after surgical treatment for shoulder instability including return to activities, pain and additional treatment or surgery.
Inclusion Criteria: Patients 12 and older with anterior, posterior or inferior shoulder instability
Principal Investigator: Grant Jones, MD
Research Coordinator: Kate Agan
Hip
Physical Activity and Symptoms in Individuals with Femoroacetabular Impingement Syndrome and ACLR
The purpose of this study is to evaluate how physical activity and loading during real-world activities are related to symptoms in those with FAIS.
Inclusion Criteria: 18-40 y.o., diagnosis of FAIS. Participants must have access to a smartphone to complete daily surveys.
Principal Investigator: Stephanie Di Stasi, PhD, PT
Research Coordinator: Stephanie.DiStasi@osumc.edu
Other trials
This study will investigate trends and correlations between dancer screening test results, medical history and injury occurrence to impact future clinical practice.
Differences in psychological and behavioral responses to pain are some of the most well studied factors that may contribute to a lack of return to sport. The purpose of this study is to determine whether preoperative psychological screening can determine future risk of an unsatisfactory outcome after sports-related knee surgery, providing risk estimation data that may allow surgeons to more appropriately recommend operative vs. conservative treatment.
Physical inactivity is a major cause for the onset and progression of bone and muscle disorders/diseases, suggesting that the human body regulates bone and muscle health together as one. Research has shown that exercise can help to prevent bone loss and strengthen bones and muscles, yet exercise is not extensively used as a therapy. In this study, we are hoping to uncover how exercise regulates bone and muscle health. Using this information, we might then be able to measure how exercise is increasing health or how to best use exercise in specific ways as therapy to increase health.
Imaging pictures from patients undergoing Magnetic Resonance Imaging (MRI) of the joint will have the option of extra Chemical Exchange Saturation Transfer (CEST) imaging sequences. The data will be reviewed for the purposes of image quality and assessing feasibility of musculoskeletal imaging.