Sethu Madhavan, MBBS
Physician, Assistant Professor
Nephrology
Make an appointment
614-293-3387
Accepting new patients
Conditions and expertise
- Nephrology
Locations
- Brain and Spine Hospital
Academics and research
Department: Internal Medicine
About
- Gender
- Male
- Additional languages
- Hindi, Malayalam
Biography
I am a board-certified nephrologist at The Ohio State University Wexner Medical Center. I specialize in diagnosing and managing complex kidney-related conditions, with a focus on chronic kidney disease, hypertension, and electrolyte disorders.
My patients can rely on me for high quality, compassionate care and honest communication in every encounter. I collaborate with a multidisciplinary team of skilled experts to ensure each patient receives personalized care tailored to their unique needs and values.
In addition to my clinical responsibilities, I am passionate about educating and mentoring the next generation of providers. I am an assistant clinical professor of Internal Medicine at The Ohio State University College of Medicine.
Conditions and expertise
- Nephrology
Locations
Please note: Not all physicians schedule patients at each listed location.
Credentials
Education
- Fellowship - Nephrology
- MetroHealth Medical Center, Cleveland, OH, United States
7/1/2010 - 6/30/2013 - Residency - Internal Medicine
- MetroHealth Medical Center, Cleveland, OH
7/1/2007 - 6/30/2010 - Internship - Internal Medicine
- Icahn School of Medicine At Mount Sinai, New York, NY, United States
7/1/2006 - 6/30/2007 - Residency - Internal Medicine
- All India Institute of Medical Sciences, New Delhi, India, India
7/1/2005 - 6/30/2006 - Residency - Internal Medicine
- All India Institute of Medical Sciences, New Delhi, India, India
7/1/2002 - 6/30/2005 - Doctor of Medicine (MD)
- Medical College Kozhikode, Kerala, India
10/1/1996 - 6/30/2002
Certifications
-
American Board of Internal Medicine/Nephrology
8/4/2015 -
American Board of Internal Medicine
8/25/2010
Academics and research
I received residency and fellowship training in the Physican Sceintist Training Program (PSTP) in Nephrology at MetroHealth/Case Western Reserve University. After my fellowship training, I joined as a faculty at the MetroHealth System from 2013-2018 and then joined OSU in 2018 in the Division of Nephrology. I am interested in understanding the molecular mechanisms of kidney chronic kidney disease pathogenesis and progression, particularly in the context of glomerular diseases.
My research over the past decade has focused on understanding the mechanisms by which variants in the APOL1 gene mediate the pathogenesis of CKD. Currently, my lab uses cultured immortalized human podocytes, human kidney biopsies, and transgenic mouse models to understand the mechanisms of APOL1 variant-mediated kidney disease. My laboratory is well equipped with state-of-the-art technology, and I have developed a collaborative approach to perform the proposed experiments.
My research is now focused on understanding how APOL1 variant proteins cause podocyte dysfunction by causing peroxisomal stress and developing therapeutic targets to mitigate APOL1 variant-associated CKD.
Research interests
- Molecular Mechanisms of Chronic Kidney Disease
- APOL1-Mediated Kidney Disease
- Podocyte Biology
Active Funding
- K08 Mentored Clinical Scientist Research Career Development Award, NIDDK 05/01/2020 – 04/30/2025
- DK123411, Sethu Madhavan, PI
- Project Title: “Apolipoprotein L1 Interaction with SNARE Proteins in the Pathogenesis of Chronic Kidney Disease”
Academic information
- Department:
- Internal Medicine
- Division:
- Nephrology
More about my research
Consulting and Related Relationships
At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.
As of 11/3/2025, Dr. Madhavan has reported no relationships with companies or entities.