Mark Wewers

Mark Wewers, MD

  • Pulmonary Disease
  • Critical Care Medicine
  • Physician

Insurances We Accept


About Me

As a pulmonary care specialist, I have a long-standing interest in diagnosing and treating patients who suffer from lung ailments. My focus is to help patients understand their disease, as knowledge promotes better adherence to treatments and helps in symptom management.

Specifically, I am passionate about alpha 1-antitrypsin (AAT) deficiency. This rare condition exists in individuals who do not produce enough AAT to protect the lungs from emphysema. I head the local Alpha-1 Research Registry, which supports patients with this condition.

In addition to my clinical work, I am a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, where my research focuses on host defense against pathogens. I seek to understand how the lung and circulating mononuclear phagocytes sense danger from pathogens and respond with robust inflammation around IL-1.

My recent studies address the important role of the inflammasome adaptor ASC as a contributor to lung airway inflammation, as well as the regulation of the pyroptosis-generating inflammasome mediator gasdermin D as a factor in lung cell survival.

The Ohio State University Wexner Medical Center brings together the best physicians in primary and specialty care. With so many expert colleagues on our team, I always know where to turn for difficult questions.
  • Rated in the top 10 percent of physicians in the nation for patient satisfaction, 2015
  • Headed first commercial alpha 1-antitrypsin (AAT) infusion study, now standard of care
  • Research lab funded for over 25 years to study mechanisms to protect the lung
  • Training and working with MD and PhD students in my laboratory for three decades
  • Best Doctor in America 2017

Procedures and Conditions I Treat

  • Asthma
  • alpha 1-Antitrypsin Deficiency
  • Sleep Disorders
  • Pulmonary Medicine
  • Pulmonary Disease, Chronic Obstructive
  • Respiratory Insufficiency
  • Respiration Disorders
  • Pulmonary Emphysema

Locations Where I Practice

Please note: Not all physicians schedule patients at each listed location. Please call the “Schedule an appointment” number shown above for scheduling assistance.

Education and Training

Education History

Medical School

Univ. of Arkansas, Little Rock, AR
9/1/1972 - 6/1/1976


University of Arkansas College of Medicine, Little Rock, AR

7/1/1976 - 6/30/1977


Univ. of Arkansas, Little Rock, AR

7/1/1977 - 6/30/1979


Univ. of Arkansas, Little Rock, AR

7/1/1979 - 6/30/1981

Board Certifications

American Board of Internal Medicine

American Board of Internal Medicine (Subspecialty: Pulmonary Disease)

Academic Information

My Department

Internal Medicine

My Division

Pulmonary, Allergy, Critical Care and Sleep Medicine

More About My Work

Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.

As of 11/01/2020, Dr. Wewers has reported no relationships with companies or entities.