Yasushi Kisanuki, MD

Physician, Associate Professor

Neurology

Make an appointment

614-293-4969
Accepting new patients

Conditions and expertise

  • Neurodegenerative Diseases
  • Ataxia
  • Neurofibroma

Locations

  • Outpatient Care Gahanna
  • Neurology

View all locations

Academic information

Department: Neurology

About

Gender
Male

Biography

I am a neurologist specializing in diagnosing and treating neurogenetic disorders of the central nervous system, including hereditary cerebellar ataxia, cerebrotendinous xanthomatosis (CTX), hereditary spastic paraplegia (HSP), leukoencephalopathy, primary lateral sclerosis (PLS) and other rare conditions. I also manage spasticity care with intrathecal Baclofen pumps in collaboration with neurosurgeons for patients with cerebral palsy, multiple sclerosis, stroke, spinal cord injury or other neurologic disorders. I have been honored as a Castle Connolly Top Doctor since 2018.

I joined The Ohio State University Wexner Medical Center as an assistant professor, and I currently serve as a clinical associate professor in the Department of Neurology. I am a Fellow of both the American Academy of Neurology and the American Neurological Association.

My research focuses on improving the diagnosis, advancing the treatments and developing therapies for genetic cerebellar ataxias, PLS, HSP and other rare neurogenetic disorders. Neurogenetic disorders often have no established cure, and even diagnosing such disorders can be a challenge that is frustrating for patients.

I have contributed to characterizing rodent models of SPG6-HSP and participated in clinical research projects on PLS and other rare conditions. Through collaborative efforts, my teams and I published diagnostic guidelines for PLS and a recommended clinical scale to measure disease severity.

Recently, I played a pivotal role in a multicenter phase 3 trial that supported Food and Drug Administration approval of chenodeoxycholic acid for CTX in February. I am currently involved in clinical studies on spinocerebellar ataxia, Friedreich ataxia, PLS and related disorders.

I organize and direct specialized clinics, including a multidisciplinary cerebellar symptom management clinic, a neurogenetic disorders clinic and a spasticity clinic that focuses on intrathecal Baclofen pumps. The access to resources and exceptional multidisciplinary teams here enable me to treat and study the most complex and rare neurologic disorders.

In addition to clinical care and research, I train future physicians as director of the Adult Neurology Residency Program, supervising medical students and resident physicians in inpatient settings and clinics. I value these interactions – our learners often ask insightful, unbiased questions about pathophysiology.

When I’m not working, I enjoy long-distance cycling, international travel and playing with my cats.

Highlights

  • Named to Castle Connolly's Regional Top Doctors list
  • Rated in the top 10 percent of physicians in the nation for patient satisfaction, 2017-2019
  • Best Doctor in America, 2017

Conditions and expertise

  • Ataxia
  • Neurodegenerative Diseases
  • Neurofibroma

Locations

Neurology

in Martha Morehouse Outpatient Care
2050 Kenny Road
Pavilion 3rd Floor Suite 3100
Columbus, OH 43221
614-293-4969

Please note: Not all physicians schedule patients at each listed location.

Credentials

Education

Fellowship - Neurology
University of Michigan Hospitals, Ann Arbor, MI, United States
7/1/2005 - 8/31/2007
Residency - Neurology
University of Michigan Hospitals, Ann Arbor, MI, United States
7/1/2002 - 6/30/2005
Internship - Other, Not Listed
St. Joseph Mercy Health System, Ann Arbor, MI, United States
7/1/2001 - 6/30/2002
Fellowship - Neurology
UT Southwestern Medical Center, Dallas, TX, United States
12/1/1994 - 6/30/2001
Residency - Geriatric Medicine
Tokyo University Hospital, Tokyo, Japan
6/1/1994 - 11/30/1994
Doctor of Medicine (MD)
University of Tokyo, Tokyo 114-0033, Japan, Japan
4/1/1990 - 3/31/1994

Certification

  • American Board of Psychiatry & Neurology-Neurology
    5/14/2006

Ratings and reviews

The overall patient satisfaction rating is an average of all patient responses to the six doctor communication related questions shown below from the Clinician and Group Consumer Assessment of Healthcare Providers and Systems survey. For additional information about the patient satisfaction survey, please visit our Patient Satisfaction Survey page.

The comments are submitted by patients and reflect their view and opinions. The comments are not endorsed by and do not necessarily reflect the views of Ohio State Wexner Medical Center.

175 Patient Satisfaction Reviews

4.9 out of 5 overall
  • Explains Things Carefully
    4.9 / 5
  • Listens Carefully
    4.9 / 5
  • Gives Understandable Instructions
    4.9 / 5
  • Knows My Medical History
    4.8 / 5
  • Shows Respect
    4.9 / 5
  • Time Spent Together
    4.9 / 5

Patient Comments

  • Reviewed on Nov 03, 2025

    He's fantastic and a genuine caring individual.8

  • Reviewed on Oct 29, 2025

    Great listener and explained everything clearly and let us ask quesrions

  • Reviewed on Oct 27, 2025

    Dr Kisanuki is very thorough and very knowledgeable. He listened to my questions and concerns. He is the best Doctor I have seen and very patient and explains everything.

  • Reviewed on Oct 06, 2025

    He understood my concerns and my interest in genetic testing

  • Reviewed on Sep 22, 2025

    Very caring & professional

Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.

As of 11/3/2025 Dr. Kisanuki has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.

  • Mirum Pharmaceuticals, Inc.

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