Biosciences Professor
460 Medical Center Drive
Room 223 (Office)
Columbus, OH 43210
614-366-1037
quan.14@osu.edu
Research Interests:
- How the immune system communicates with the central nervous system
- How mental disorders can be produced from immunological activities
- How nerve innervation can modulate immune responses
- The function of the neuroimmune suprasystem
Research Techniques: Dr. Quan creates and uses genetic mouse models to investigate how different types of inflammation signals the CNS via specific cell types.
Selected Publications:
Interleukin 1 type 1 receptor restore: A genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types Liu, X., Yamashita, T., Chen, Q., Belevych, N., McKim, D. B., Tarr, A. J., Coppola, V., Nath, N., Nemeth, D. P., Syed, Z. W., Sheridan, J. F., Godbout, J. P., Zuo, J. & Quan, N. Feb 18 2015 In : Journal of Neuroscience. 35, 7, p. 2860-2870 11 p.
Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury An, Y., Belevych, N., Wang, Y., Zhang, H., Nasse, J. S., Herschman, H., Chen, Q., Tarr, A., Liu, X. & Quan, N. May 21 2014 In : Journal of Inflammation Research. 7, 1, p. 57-67 11 p.
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge An, Y., Belevych, N., Wang, Y., Zhang, H., Herschman, H., Chen, Q. & Quan, N. Apr 1 2014 In : Journal of Neuroscience Research. 92, 4, p. 486-495 10 p.
Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P. & Sheridan, J. F. Feb 14 2014 In : Journal of Neuroscience. 34, 7, p. 2583-2591 9 p.
In-depth conversation: Spectrum and kinetics of neuroimmune afferent pathways Quan, N. Jan 1 2014 In : Brain, Behavior, and Immunity. 40, p. 1-8 8 p.
Kinetic characteristics of euflammation: The induction of controlled inflammation without overt sickness behavior Tarr, A. J., Liu, X., Reed, N. S. & Quan, N. Jan 1 2014 In : Brain, Behavior, and Immunity. 42, p. 96-108 13 p.
Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron Lieblein-Boff, J. C., Mckim, D. B., Shea, D. T., Wei, P., Deng, Z., Sawicki, C., Quan, N., Bilbo, S. D., Bailey, M. T., Mctigue, D. M. & Godbout, J. P. Oct 14 2013 In : Journal of Neuroscience. 33, 41, p. 16334-16345 12 p.
Networking into neural plasticity: A rising score on the cytokine learning curve Quan, N. Oct 1 2013 In : Brain, Behavior, and Immunity. 33
Controlled progressive innate immune stimulation regimen prevents the induction of sickness behavior in the open field test Chen, Q., Tarr, A. J., Liu, X., Wang, Y., Reed, N. S., DeMarsh, C. P., Sheridan, J. F. & Quan, N. Jul 15 2013 In : Journal of Inflammation Research. 6, 1, p. 91-98 8 p.
Neural and behavioral responses to low-grade inflammation Tarr, A. J., Chen, Q., Wang, Y., Sheridan, J. F. & Quan, N. Dec 1 2012 In : Behavioural Brain Research. 235, 2, p. 334-341 8 p.
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase Qian, J., Zhu, L., Li, Q., Belevych, N., Chen, Q., Zhao, F., Herness, S. & Quan, N. Jul 24 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. 12189-12194 6 p.
Interleukin-1exerts distinct actions on different cell types of the brain in vitro An, Y., Chen, Q. & Quan, N. Mar 28 2011 In : Journal of Inflammation Research. 4, 1, p. 11-20 10 p.
Endothelial IL-1R1 is a critical mediator of EAE pathogenesis Li, Q., Powell, N., Zhang, H., Belevych, N., Ching, S., Chen, Q., Sheridan, J., Whitacre, A. & Quan, N. Jan 1 2011 In : Brain, Behavior, and Immunity. 25, 1, p. 160-167 8 p.
Altered expression of circadian rhythm genes among individuals with a history of depression Gouin, J. P., Connors, J., Kiecolt-Glaser, J. K., Glaser, R., Malarkey, W. B., Atkinson, C., Beversdorf, D. & Quan, N. Oct 1 2010 In : Journal of Affective Disorders. 126, 1-2, p. 161-166 6 p.
Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation Belevych, N., Buchanan, K., Chen, Q., Bailey, M. & Quan, N. Oct 1 2010 In : Brain, Behavior, and Immunity. 24, 7, p. 1137-1147 11 p.
The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1 Reiser, P. J., Bicer, S., Patel, R., An, Y., Chen, Q. & Quan, N. May 15 2010 In : Journal of Experimental Biology. 213, 10, p. 1633-1642 10 p.
Existence of seven human IL-1R1 promoters Li, Q., Zhang, H., Chen, Q. & Quan, N. Apr 29 2010 In : Journal of Inflammation Research. 3, 1, p. 17-24 8 p.
Education:
PhD: University of Tennessee
Postdoctoral Training:
Neuroimmunology, National Institute of Mental Health
Honors/News:
1988 Third Prize. Student Research in Neuroscience.
1990 Second Prize. Student Research in Neuroscience.
1998 Invited Speaker. Taniguchi Foundation, Japan.