Felts Mercer Professor of Medicine and Pharmacology
Director, Center for Pharmacogenomics
College of Medicine
Department of Molecular Immunology, Virology and Medical Genetics
Center for Pharmacogenomics
5078 Graves Hall
333 W. 10th Avenue
Columbus OH 43210-1239
Phone: 614-292-5593
Fax: 614-292-7232
wolfgang.sadee@osumc.edu
Research Interests: Pharmacogenomics, personalized/genomic medicine
Research Lab Goals: The Center for Pharmacogenomics pursues the discovery of genetic variants that can serve as biomarkers guiding successful drug therapy in individual patients. Researchers at the center have developed new approaches for the discovery of genetic variants, with a focus on gene regulation, including innovative genome-scale technologies, such as massively parallel sequencing, and data integration using large-scale data repositories.
Current Research: Regulatory variants in genes involved in cardiovascular and central nervous system disorders, innate immunity and drug metabolism; systems biology using transcriptomes; and clinical relevance
Research Techniques: Molecular genetics methodologies, next-generation sequencing, bioinformatics, mathematical modeling, large-scale data analytics
Active Funding:
- 2010-2016, Expression Genetics of Drug Therapy, NIH, $9.1 million
- 2010-2015, Pharmacogenomic Evaluation of Antihypertensive Responses, NIH, ~$400,000
- 2011-2015, Pharmacogenomics Implementation, NIH, ~$180,000
- 2011-2015, Next-generation Sequencing for CNS, NIH, ~$480,000
- 2012, Genomic studies on Dementia with Lewy Bodies
- Mangurian Foundation, $100,000
- 2012, Clinical pharmacogenomics studies, Sub-contract from the OSUMC CTSA, grant from the National Center for Research Resources, $50,000
- 2012-2015, Genomic studies on autism spectrum disorders, Department of Defense subcontract from Nationwide Children's Hospital, $450,000
- 2014-2015, Molecular genetics and genomics of vortioxetine (Brintellix), Takeda Pharmaceuticals, $92,700
- 2015, Molecular genetics and genomics of vortioxetine (Brintellix), Takeda Pharmaceuticals, $105,000
- 2015-2017, Alveolar macrophage immunobiology and functional genomics: Unlocking human to human variation in host response to M. tuberculosis,
- Gates Foundation, $599,000
Education:
N/A, Pharmacy, ETH Zurich
Apotheker, Pharmacy, Free University of Berlin
Dr. rer. nat., Pharmaceutical Chemistry, Free University of Berlin
Fellowships:
Postdoctoral Fellow (NATO)
Department of Pharmaceutical Chemistry, University of California San Francisco
Research Associate, Fellowship (Deutsche Forschungs Gemeinschaft)
School of Pharmacy and Clinical Pharmacology, Freie Universität Berlin, Germany
- 1981 Fellow, Humboldt Foundation, Germany
- 1991 Research Achievement Award in Biotechnology (first recipient), American Association of Pharmaceutical Scientists
- 1994 Distinguished Service Award, American Association of Pharmaceutical Scientists
- Fellow, American Association of Pharmaceutical Scientists
- Certificate of Appreciation as Founding Editor, Pharmaceutical Research, American Association of Pharmaceutical Scientists
- Paul Dawson Award in Biotechnology, American Association of Colleges of Pharmacy
- 1996 Certificate of Appreciation, University of California Health Sciences Committee
- 1999 Phoenix Wissenschaftspreis 1999 for outstanding scientific research paper with pharmaceutical relevance (coauthor in Biochem. 37, 16582-16590 (1998)
- 2001 Avis Distinguished Visiting Professor, University of Tennessee
- The Nagai Foundation Tokyo, Distinguished Lectureship 2001
- Distinguished Pharmaceutical Scientist Award, American Association of Pharmaceutical Scientists
- 2002 Honorary Lecturer, 22nd Annual Graduate Student Symposium in the Pharmacological Sciences and Bio-related Chemistry. University of Michigan
- Opening Plenary Speaker, First AAPS National Biotechnology Conference, San Diego
- Distinguished Lecturer, Frontiers in Chemistry, Case Western Reserve University
- 2003 47th Annual Julius A. Koch Lecture, University of Pittsburgh
- Fellow, American Association for the Advancement of Science
- 2004 Presidential Citation, AAPS
- 2005 Plenary Lecturer, 34th Ann. Meeting, New England Pharmacologists
- U.S. Food and Drug Administration, Advisory Committee Service Award
- 2007 Keynote Speaker. University of Texas at Austin, College of Pharmacy “Celebrating Research Achievements”. April.
- 2011 College of Medicine nominee for The Ohio State Innovator of the Year Award
- 2013 Distinguished Scholar Award at The Ohio State University
- 2013 David Chu Lecturership, University of New York in Buffalo