Physician, Professor
Neurology
Department: Neurology
I am a neurologist with subspecialty expertise in multiple sclerosis (MS) and related neuroimmunological disorders. At The Ohio State University Wexner Medical Center, I serve as chair of the Department of Neurology, as director of the Neuroscience Research Institute, and as co-director of the Neurological Institute, where I lead programs that integrate the latest research, clinical care and education to improve outcomes for individuals with neurological diseases.
My clinical practice focuses on delivering highly personalized care for patients with MS and other immune-mediated disorders of the brain and spinal cord. Because MS affects each person differently, my goal is to design treatment plans tailored to every patient’s unique disease course and lifestyle. At our MS and Neuroimmunology Center, we use the latest diagnostic tools and advanced therapies to prevent relapses, limit new lesion formation and preserve neurological function. Above all, our mission is to enhance our patients’ quality of life and long-term health.
I’ve been named to the “Best Doctors in America” and Castle Connolly “Top Doctors” lists every year since 2010, and have received numerous honors, including the Harry Weaver Neuroscience Scholar Award from the National Multiple Sclerosis Society. I’ve authored more than 115 peer-reviewed publications and frequently serve as a keynote speaker at national and international conferences.
I am also deeply involved in the professional MS community, serving as director and president-elect of the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) and chairing several of its educational and scientific programs. Through these efforts, I remain committed to advancing discovery, innovation and compassionate care for people with MS and other neuroimmunological diseases.
Please note: Not all physicians schedule patients at each listed location.
My research explores how the immune system interacts with the central nervous system during MS and other inflammatory conditions. We've shown that the pattern of inflammation and tissue injury can differ from one individual to another, underscoring the need for precision medicine in MS care. Current studies focus on identifying biomarkers that predict disease progression and treatment response, and on uncovering mechanisms that promote repair and regeneration in the nervous system. Our work is supported by continuous National Institutes of Health (NIH) funding, and has been published in leading journals, such as Nature Immunology, Annals of Neurology, The Journal of Clinical Investigation, Proceedings of the National Academy of Sciences and Lancet Neurology.
Over $1.3 million in annual funding for research in multiple sclerosis and neuroimmunology
At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.
As of 11/3/2025 Dr. Segal has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.