Wendy Frankel, MD

Physician, Emeritus in the College of Medicine

Pathology

Wendy Frankel

Contact our office

614-293-8000

Appointments cannot be scheduled directly with this provider.

Conditions and expertise

  • Gastrointestinal Diseases
  • Liver Cancers
  • Gastrointestinal Cancers
  • Liver Diseases
  • Pancreatic Diseases
  • Pancreatic Cancers

View all conditions

Locations

  • The Ohio State University Wexner Medical Center

View location details

Academics and research

Department: Pathology

View my research

About

Gender
Female

Biography

I am a pathologist specializing in patients with pancreatic s and gastrointestinal cancers and diseases. I serve as Emeritus and Distinguished Professor of the Department of Pathology at The Ohio State University Wexner Medical center and was the Department Chair from 2014-2024.

I received my medical degree from the University of Michigan and trained in The Department of Surgery at the Hospital of the University of Pennsylvania. I completed my residency in Anatomic and Clinical pathology at University of California San Diego and my surgical pathology fellowship at the University of California San Francisco.

As a member of the Translational Therapeutics Program at the OSUCCC – James, my research focuses on colorectal carcinoma, specifically in the area of colon cancer genetics. I was part of the Columbus-area Hereditary Non-Polyposis Colorectal Cancer (HNPCC) study that changed the standard of care for colorectal cancer patients in the United States. I was also involved with the Ohio Colorectal Cancer Prevention Initiative (OCCPI), which screened newly diagnosed colorectal cancer patients across the state and their at-risk relatives for Lynch syndrome. My other areas of focus are Biobanking and Digital and Computational Pathology. I am the GI Pathology Cadre leader of Pathology for Alliance for Clinical Trials and Oncology. Over the course of my career, I have published more than 250 papers and multiple reviews and chapters and given numerous lectures both nationally and internationally.

What I love most about working at the OSUCCC – James is the community of experienced medical professionals, researchers and caring staff. At The James, we have access to the latest research and technology, and together, we use these resources to provide targeted treatment plans to our patients. Each person’s cancer is different, and we treat each patient according to their needs. Together, we’re working towards a cancer-free world, and I’m proud to be a part of this mission.

Highlights

  • Named to Castle Connolly's Top Doctors and Exceptional Women in Medicine
  • Past Chair and COM Distinguished Professor, Department of Pathology, The Ohio State University
  • Past President Mazzaferri-Ellison Society of Master Clinicians at The Ohio State University Wexner Medical Center
  • Past President United States and Canadian Academy of Pathology
  • Past President Rodger Haggitt Gastrointestinal Pathology Society
  • Dean's Award for Lifetime Achievement in Education, The Ohio State University College of Medicine
  • Consortium site PI for Alliance NCTN Biorepository and Biospecimen Resource (U24CA196171), The Ohio State University

Conditions and expertise

  • Gastrointestinal Cancers
  • Gastrointestinal Diseases
  • Liver Cancers
  • Liver Diseases
  • Pancreatic Cancers
  • Pancreatic Diseases

Locations

Please note: Not all physicians schedule patients at each listed location.

Credentials

Education

Fellowship - Surgical Pathology
University of California San Francisco School of Medicine, San Francisco, CA, United States
7/1/1996 - 6/30/1997
Residency - Pathology, Anatomic Pathology & Clinical Pathology
University of California Medical Center San Diego, San Diego, CA, United States
7/1/1993 - 6/30/1996
Fellowship - Surgery (General Surgery)
Hospital of the University of Pennsylvania, Philadelphia, PA, United States
7/1/1991 - 6/30/1993
Residency - Surgery (General Surgery)
Hospital of the University of Pennsylvania, Philadelphia, PA, United States
6/1/1988 - 6/1/1993
Doctor of Medicine (MD)
University of Michigan Medical School, Ann Arbor, MI, United States
8/1/1984 - 5/1/1988

Certification

  • American Board of Pathology/Anatomic & Clinical
    11/13/1996

Academics and research

I am a Distinguished University Professor of Pathology and holder of the Ralph W. and Helen Kurtz Chair in Pathology at The Ohio State University. I also chair the Department of Pathology in the College of Medicine, serve as director of the GI/Liver Fellowship and am a member of the Translational Therapeutics Program at the OSUCCC - James.

My primary research interest is colorectal carcinoma and colorectal cancer genetics. I was part of a team that carried out the Columbus-area Hereditary Non-Polyposis Colorectal Cancer (HNPCC) study to determine the prevalence of Lynch syndrome (LS) among all newly diagnosed colorectal and endometrial (uterine) cancer patients.

Results from this study and subsequent publications have changed the standard of care for colorectal cancer patients in the United States, as many institutions have adopted the study’s recommendations to screen these patients for LS (which predisposes to several types of cancer) using immunohistochemistry staining for the four mutated genes that cause it.

I was also involved with the Ohio Colorectal Cancer Prevention Initiative launched by the OSUCCC - James to screen newly diagnosed colorectal cancer patients across the state and their at-risk relatives for LS.

Research interests

  • Colorectal Neoplasms
  • Colorectal Neoplasms Hereditary Nonpolyposis
  • Computational Biology
  • DNA Repair
  • Deep Learning
  • Gastrointestinal Neoplasms
  • Genetic Predisposition to Disease
  • Machine Learning
  • Neoplastic Syndromes Hereditary
  • Pancreatic Neoplasms

Academic information

Department:
Pathology
Division:
Pathology

More about my research

Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the University requires annual disclosures from all faculty members with external interests related to their University responsibilities.

As of 11/3/2025, Dr. Frankel has reported no relationships with companies or entities.

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