Internationally recognized for his work in multiple sclerosis (MS) and neuroimmunology, with annual NIH research funding in excess of $1.3 million
The Segal lab studies interactions between the immune system and central nervous system (CNS), both in disease and in repair.
Active projects include investigations into the pathogenesis of multiple sclerosis (MS) using the animal model, experimental autoimmune encephalomyelitis (EAE), as well as the analysis of patient samples in association with MRI and clinical metrics. The goal is to understand how the immune system is dysregulated in MS, how immune cells gain access to the CNS, and how immune cells interact with glial cells, neurons and axons to either cause damage or initiate disease remission.
Another major interest of the lab is immune-driven CNS repair in the setting of neurodegenerative disease or in the aftermath CNS trauma.
Exploring novel MS treatments, including a targeted dance program for increased motor function, brain connectivity, and wellness in multiple sclerosis and a comparison study of the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis.
Dr. Yang is interested in understanding molecule mechanisms that regulate CNS autoimmunity, with the goals of both identifying therapeutic targets and developing innovative therapies to treat patients.
The mission of the Guerau Applied Immunology Laboratory is to provide better diagnostic biomarkers and therapeutic targets for Multiple Sclerosis (MS) that reduce and/or stop disease. To do so, we investigate epigenetic mechanisms that promote inflammatory immune cells and drive inflammation/autoimmunity.
Dr. Prakash’s research interest is in using imaging techniques to understand the behavioral and neural correlates of cognitive dysfunction in MS.
To review currently available studies, click here.