Annual Retreat and Educational Events
Our mission is to create a world-class infrastructure and collaborative community that facilitates interdisciplinary research of neurological disease and injury, to build bridges between innovative translational neuroscience research and clinical implementation, and to foster educational and professional development opportunities for junior investigators in the field.
The Neuroscience Research Institute (NRI) was created to enhance the quality and breadth of neurological-related research at Ohio State by providing an infrastructure with an emphasis on translating research discoveries into clinical interventions. Comprehensive resources include an integrative brain bank and biorepository, mentorship and career development opportunities for junior investigators, and world-class educational symposiums. Another goal of the NRI is to foster cross-campus interdisciplinary collaborations with an emphasis in animal model, high-throughput assay and experimental therapeutic development.
Our NRI Leaders
Benjamin Segal, MD
Chair, Department of Neurology; Director, Neuroscience Research Institute Co-director, Neurological Institute
Erica Bell, PhD
Associate Director, Neuroscience Research Institute; Associate Professor, Department of Neurology
About the NRI
Brain Bank & Biorepository (NRI-BBB)
The goal of the Neurology Research Institute Brain Bank & Biorepository (NRI-BBB) is to establish a state of the art brain bank and biorepository at The Ohio State University to facilitate novel research and clinical trials using samples collected by clinicians directly involved in patient care. Patient samples collected and stored within the NRI-BBB includes, but is not limited to CSF, blood, autopsy and surgical and/or biopsy specimens.
About the NRI-BBB
Jonathan Roell, MBBS
Jonathan Roell joined the Neuroscience Research Institute at The Ohio State University in September of 2021 as a Research Associate and handles the processing, storage and maintenance of samples submitted to the NRI-Brain Bank and Biorepository. He received his B.S. from the University of Florida in Engineering Sciences before working at the CDC investigating foamy virus as a potential vaccine vector. He then spent six years in Beijing where he received his MBBS from China’s Capital Medical University. Jonathan’s most recent position prior to joining OSU was as a molecular technologist at OSF St. Francis Medical Center where his team was tasked with developing large scale COVID-19 testing at the onset of the pandemic. As a member of the NRI-BBB team, Jonathan plays an integral role in expanding the NRI-Brain Bank and Biorepository which supports translational research across OSU’s College of Medicine.
Michael Rose, BS MB(ASCP)CM
Michael Rose joined the Neuroscience Research Institute in September 2021 beginning his role as Laboratory Supervisor for the NRI-BBB. Michael received his Bachelors of Science in Cell and Molecular Biology from Kent State University. After graduating, Michael spent 9 years at Nationwide Children’s Hospital where he was a lead team member for their own biorepository. He then later transitioned to a role on the clinical genetics team where he tested for a variety of genetic inherited diseases and cancer. During this time Michael also received his certification in Molecular Biology from American Society for Clinical Pathology. Michael later joined the next generation sequencing team in the Institute for Genomic Medicine at Nationwide Children’s Hospital. In this role, he performed a variety of library constructions for sequencing, loaded and maintained the sequencers, and investigated NGS findings. Michael is passionate about improving processes for the better of the laboratory and building relationships across work groups. Michael is looking forward to continuing to grow here at Ohio State while bringing his own experience and skill sets to the NRI.
Tom Liu, MD, PhD
Tom Liu joined the Segal Lab within the Department of Neurology in 2020 and his significant roles include designing, overseeing, and performing the molecular, cellular, and immunologic studies on all neuron-regeneration projects. As a senior scientist, he participated in the development of the Neuroscience Research Institute’s protocols and pipelines for biorepository collection, processing, and storage and is one of the major contributors in biological processing on multiple ongoing clinical trial protocols. Most recently, he established and currently oversees all aspects of the genomic medicine pipeline within the Segal Lab and the Neuroscience Research Institute. His primary roles are to design experiments, process samples, and library preparations of a variety of next generation sequencing projects including genomic, whole transcriptomic (RNAseq), and single cell (10X) library preparation.
Former Lab Team Members
- Samruddhi Ubhe, BS
Neuroscience Research Institute
Biorepository Fee Structure
(previously collected samples)
| Specimen Type | |
Cost |
|---|---|---|
| Plasma (500μL) | |
$25 |
| Serum (500μL) | |
$25 |
| PBMCs (vial ~4E^6 cells) | |
$65 |
| CSF Supernatant (500μL) | |
$50 |
| CSF Cell Pellet | |
$200 |
| DNA Aliquot (1μg) | |
$40 |
| Sample storage fee -80 (box) per year | |
$35 |
| Technologist time per hour (15min intervals) | |
$30 |
Please reach out to NRI-BBB@osumc.edu for prospective sample banking.
Neuroscience Research Institute
Brain Bank Fee Structure
| Specimen Type | |
Cost |
|---|---|---|
| Frozen brain tissue request (slice, approximately 1 cm) | |
$225 |
*If macro-dissection is needed, price will vary and depend on neuropath availability
**Frozen brain hemisphere tissue storage fees may apply for prospective projects
NRI Collaboration Tool
If you are looking for a neuroscience-related collaborator, complete the request form and the NRI will assist with identifying a potential collaborator.
Center for Neurobiology of Aging and Resiliency (CNAR)
The Center for Neurobiology of Aging and Resiliency (CNAR) is a translational research center within the Neurological Research Institute that’s focused on understanding and optimizing aging of the nervous system. The risk for developing neurological disorders increases with age, and many geriatric syndromes are largely explained by neurological dysfunction. Because the global population is aging rapidly, optimizing neurologic health in older adults is imperative. CNAR aims to translate research discoveries to improve health-span and function in older adults using multidisciplinary and integrative approaches. We focus on three main areas:
- healthy aging and resiliency
- age-related neurodegeneration
- aging with a neurological disorder